Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2)

Min Wang, David X. Zheng, Michael B. Luo, Mingzhang Gao, Kathy D. Miller, Gary D. Hutchins, Qi Huang Zheng

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Carbon-11-labeled tariquidar derivatives were first designed and synthesized as new PET agents for imaging of breast cancer resistance protein. The target tracers were prepared by O-[11C]methylation of their corresponding acid precursors using [11C]CH3OTf under basic conditions and isolated by a simplified solid-phase extraction (SPE) method in 50-60% radiochemical yields based on [11C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 111-185 GBq/μmol.

Original languageEnglish (US)
Pages (from-to)1098-1103
Number of pages6
JournalApplied Radiation and Isotopes
Volume68
Issue number6
DOIs
StatePublished - Jun 1 2010

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Keywords

  • Breast cancer resistance protein
  • Imaging
  • Positron emission tomography
  • Radiotracers
  • Tariquidar derivatives

ASJC Scopus subject areas

  • Radiation

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