Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2)

Min Wang, David X. Zheng, Michael B. Luo, Mingzhang Gao, Kathy Miller, Gary Hutchins, Qi-Huang Zheng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Carbon-11-labeled tariquidar derivatives were first designed and synthesized as new PET agents for imaging of breast cancer resistance protein. The target tracers were prepared by O-[11C]methylation of their corresponding acid precursors using [11C]CH3OTf under basic conditions and isolated by a simplified solid-phase extraction (SPE) method in 50-60% radiochemical yields based on [11C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 111-185 GBq/μmol.

Original languageEnglish
Pages (from-to)1098-1103
Number of pages6
JournalApplied Radiation and Isotopes
Volume68
Issue number6
DOIs
StatePublished - Jun 2010

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breast
bombardment
cancer
proteins
methylation
carbon
synthesis
tracers
solid phases
purity
acids
decay

Keywords

  • Breast cancer resistance protein
  • Imaging
  • Positron emission tomography
  • Radiotracers
  • Tariquidar derivatives

ASJC Scopus subject areas

  • Radiation

Cite this

Synthesis of carbon-11-labeled tariquidar derivatives as new PET agents for imaging of breast cancer resistance protein (ABCG2). / Wang, Min; Zheng, David X.; Luo, Michael B.; Gao, Mingzhang; Miller, Kathy; Hutchins, Gary; Zheng, Qi-Huang.

In: Applied Radiation and Isotopes, Vol. 68, No. 6, 06.2010, p. 1098-1103.

Research output: Contribution to journalArticle

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