Carbon-11-labeled tricyclic necroptosis inhibitors were first designed and synthesized as new potential PET agents for imaging of tumor necrosis factor α (TNF-α). The target tracers were prepared by O-[ 11C]methylation of their corresponding precursors using [ 11C]CH 3OTf under basic conditions and isolated by a simplified SPE method in 50-60% radiochemical yields based on [ 11C]CO 2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 15-20min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 111-185GBq/γmol.
- Positron emission tomography
- Tricyclic necroptosis inhibitors
- Tumor necrosis factor
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