Synthesis of carbon-11-labeled tricyclic necroptosis inhibitors as new potential PET agents for imaging of tumor necrosis factor α (TNF-α)

Mingzhang Gao, Christian M. Lola, Min Wang, Kathy D. Miller, George W. Sledge, Gary D. Hutchins, Qi Huang Zheng

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Carbon-11-labeled tricyclic necroptosis inhibitors were first designed and synthesized as new potential PET agents for imaging of tumor necrosis factor α (TNF-α). The target tracers were prepared by O-[ 11C]methylation of their corresponding precursors using [ 11C]CH 3OTf under basic conditions and isolated by a simplified SPE method in 50-60% radiochemical yields based on [ 11C]CO 2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 15-20min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 111-185GBq/γmol.

Original languageEnglish (US)
Pages (from-to)1950-1958
Number of pages9
JournalApplied Radiation and Isotopes
Volume68
Issue number10
DOIs
StatePublished - Oct 1 2010

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Keywords

  • Imaging
  • Positron emission tomography
  • Radiotracers
  • Tricyclic necroptosis inhibitors
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Radiation

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