Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents

Mingzhang Gao, Deyuan Kong, Abraham Clearfield, Kathy Miller, George W. Sledge, Qi-Huang Zheng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.

Original languageEnglish
Pages (from-to)2301-2304
Number of pages4
JournalSynthesis
Issue number14
DOIs
StatePublished - Jul 17 2006

Fingerprint

Positron emission tomography
Pemetrexed
Carbon
Imaging techniques
Propionic acid
Esters
Crystal structure
Single crystals
propionic acid
acetamide
1-phenyl-1-aminomethylethene

Keywords

  • 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [C]methyl ester
  • Imaging agents
  • Melanoma cancer
  • N-(4-[c]methoxyphenyl)-2,2,2- triphenylacetamide
  • Positron emission tomography
  • Triphenylacetamides

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents. / Gao, Mingzhang; Kong, Deyuan; Clearfield, Abraham; Miller, Kathy; Sledge, George W.; Zheng, Qi-Huang.

In: Synthesis, No. 14, 17.07.2006, p. 2301-2304.

Research output: Contribution to journalArticle

Gao, Mingzhang ; Kong, Deyuan ; Clearfield, Abraham ; Miller, Kathy ; Sledge, George W. ; Zheng, Qi-Huang. / Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents. In: Synthesis. 2006 ; No. 14. pp. 2301-2304.
@article{7bcb559a80c44387bab0bf138752b002,
title = "Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents",
abstract = "New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.",
keywords = "3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [C]methyl ester, Imaging agents, Melanoma cancer, N-(4-[c]methoxyphenyl)-2,2,2- triphenylacetamide, Positron emission tomography, Triphenylacetamides",
author = "Mingzhang Gao and Deyuan Kong and Abraham Clearfield and Kathy Miller and Sledge, {George W.} and Qi-Huang Zheng",
year = "2006",
month = "7",
day = "17",
doi = "10.1055/s-2006-942442",
language = "English",
pages = "2301--2304",
journal = "Synthesis",
issn = "0039-7881",
publisher = "Georg Thieme Verlag",
number = "14",

}

TY - JOUR

T1 - Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents

AU - Gao, Mingzhang

AU - Kong, Deyuan

AU - Clearfield, Abraham

AU - Miller, Kathy

AU - Sledge, George W.

AU - Zheng, Qi-Huang

PY - 2006/7/17

Y1 - 2006/7/17

N2 - New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.

AB - New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.

KW - 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [C]methyl ester

KW - Imaging agents

KW - Melanoma cancer

KW - N-(4-[c]methoxyphenyl)-2,2,2- triphenylacetamide

KW - Positron emission tomography

KW - Triphenylacetamides

UR - http://www.scopus.com/inward/record.url?scp=33746613678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746613678&partnerID=8YFLogxK

U2 - 10.1055/s-2006-942442

DO - 10.1055/s-2006-942442

M3 - Article

AN - SCOPUS:33746613678

SP - 2301

EP - 2304

JO - Synthesis

JF - Synthesis

SN - 0039-7881

IS - 14

ER -