Synthesis of carbon-11 labeled triphenylacetamides as novel potential PET melanoma cancer imaging agents

Mingzhang Gao, Deyuan Kong, Abraham Clearfield, Kathy D. Miller, George W. Sledge, Qi Huang Zheng

Research output: Contribution to journalArticle

3 Scopus citations


New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.

Original languageEnglish (US)
Pages (from-to)2301-2304
Number of pages4
Issue number14
StatePublished - Jul 17 2006



  • 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [C]methyl ester
  • Imaging agents
  • Melanoma cancer
  • N-(4-[c]methoxyphenyl)-2,2,2- triphenylacetamide
  • Positron emission tomography
  • Triphenylacetamides

ASJC Scopus subject areas

  • Organic Chemistry

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