New carbon-11 labeled triphenylacetamides (TPAs), N-(4-[ 11C]methoxyphenyl)-2,2,2-triphenyl-acetamide ([11C]MTA) and 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [ 11C]methyl ester ([11C]PAME), were designed and synthesized as potential positron emission tomography (PET) melanoma cancer imaging agents. The single crystal structure of the potent anti-melanoma agent, N-(4-methoxyphenyl)-2,2,2-triphenylacetamide (MTA) is reported.
- 3-phenyl-(R)-2-(2,2,2-triphenylacetylamino)propionic acid [C]methyl ester
- Imaging agents
- Melanoma cancer
- N-(4-[c]methoxyphenyl)-2,2,2- triphenylacetamide
- Positron emission tomography
ASJC Scopus subject areas
- Organic Chemistry