Synthesis of chiral 2-(4-phenoxyphenylsulfonylmethyl)thiiranes as selective gelatinase inhibitors

Mijoon Lee, M. Margarida Bernardo, Samy O. Meroueh, Stephen Brown, Rafael Fridman, Shahriar Mobashery

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

(Chemical Equation Presented) Compound 1, 2-(4-phenoxyphenylsulfonylmethyl) thiirane, is a selective inhibitor of gelatinases, which is showing high promise in studies of animal models for cancer metastasis and stroke. The (R)-1 and (S)-1 enantiomers of compound 1 were each synthesized in this study and were shown to be equally active in inhibition of gelatinases.

Original languageEnglish (US)
Pages (from-to)4463-4465
Number of pages3
JournalOrganic Letters
Volume7
Issue number20
DOIs
StatePublished - Sep 29 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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