Synthesis of MMP inhibitor radiotracer [11C]CGS 25966, a new potential PET tumor imaging agent

Xiangshu Fei, Qi-Huang Zheng, Xuan Liu, Ji Quan Wang, K. Lee Stone, Kathy Miller, George W. Sledge, Gary Hutchins

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

[11C]CGS 25966, a novel radiolabeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agent. The precursor was labeled by [11C]methyl triflate through O-[11C]methylation method at the hydroxyl position of phenol under basic conditions and isolated by HPLC purification to produce pure target compound in 15-25% radiochemical yield, based on 11CO2, decay corrected to end of bombardment.

Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number4
DOIs
StatePublished - Mar 30 2003

Fingerprint

Positron emission tomography
Methylation
Matrix Metalloproteinase Inhibitors
Phenol
Hydroxyl Radical
Positron-Emission Tomography
Purification
Tumors
High Pressure Liquid Chromatography
Imaging techniques
Neoplasms
N-hydroxy-2-(((4'-methoxyphenyl)sulfonyl)benzylamino)-3-methylbutanamide
methyl triflate

Keywords

  • [C]CGS 25966
  • Carbon-11
  • Matrix metalloproteinase inhibitor
  • Positron emission tomography
  • Radiotracer
  • Tumor imaging agent

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Synthesis of MMP inhibitor radiotracer [11C]CGS 25966, a new potential PET tumor imaging agent. / Fei, Xiangshu; Zheng, Qi-Huang; Liu, Xuan; Wang, Ji Quan; Stone, K. Lee; Miller, Kathy; Sledge, George W.; Hutchins, Gary.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, No. 4, 30.03.2003, p. 343-351.

Research output: Contribution to journalArticle

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