Synthesis of MMP inhibitor radiotracer [11C]CGS 25966, a new potential PET tumor imaging agent

Xiangshu Fei, Qi Huang Zheng, Xuan Liu, Ji Quan Wang, K. Lee Stone, Kathy D. Miller, George W. Sledge, Gary D. Hutchins

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

[11C]CGS 25966, a novel radiolabeled matrix metalloproteinase (MMP) inhibitor, has been synthesized for evaluation as new potential positron emission tomography (PET) tumor imaging agent. The precursor was labeled by [11C]methyl triflate through O-[11C]methylation method at the hydroxyl position of phenol under basic conditions and isolated by HPLC purification to produce pure target compound in 15-25% radiochemical yield, based on 11CO2, decay corrected to end of bombardment.

Original languageEnglish (US)
Pages (from-to)343-351
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
Issue number4
DOIs
StatePublished - Mar 30 2003

Keywords

  • [C]CGS 25966
  • Carbon-11
  • Matrix metalloproteinase inhibitor
  • Positron emission tomography
  • Radiotracer
  • Tumor imaging agent

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

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