Synthesis of new carbon-11 labeled cyclofenil derivatives for PET imaging of breast cancer estrogen receptors

Mingzhang Gao, Min Wang, Bruce H. Mock, Kathy D. Miller, George W. Sledge, Gary D. Hutchins, Qi Huang Zheng

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Carbon-11 labeled cyclofenil derivatives, [11C]methyl-2-{4-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([11C]16a), [11C]methyl-4-[bis(4-hydroxyphenyl)methylene]cyclohexanecarboxylate ([11C]16b), [11C]methyl-2-{3-[bis(4-hydroxyphenyl)methylene]cyclohexyl}acetate ([11C]18a), and [11C]methyl-3-[bis(4-hydroxyphenyl)methylene]cyclohexanecarboxylate ([11C]18b), have been synthesized as new potential PET agents for imaging breast cancer estrogen receptors. The target tracers were prepared by O-[11C]methylation of their corresponding precursors using [11C]CH3OTf and isolated by a simplified SPE purification procedure in 35-50% radiochemical yields decay corrected to EOB, 15-20 min overall synthesis time, and 74-111 GBq/μmol specific activity at EOS.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalApplied Radiation and Isotopes
Volume66
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Breast cancer
  • Carbon-11
  • Cyclofenil derivatives
  • Estrogen receptors
  • Imaging
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Radiation

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