Synthesis of new carbon-11 labeled naphthalene-sulfonamides for PET imaging of human CCR8

Min Wang, Benjamin Cooley, Mingzhang Gao, Kathy Miller, George W. Sledge, Gary Hutchins, Qi-Huang Zheng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Carbon-11 labeled naphthalene-sulfonamides, N-(4-(N-(4-[11C]methoxyphenyl)sulfamoyl)naphthalene-1-yl)benzamide ([11C]5a), N-(4-(N-(4-[11C]methoxyphenyl)sulfamoyl)naphthalene-1-yl)-2-methylbenzamide ([11C]5b), N-(4-(N-(4-[11C]methoxyphenyl)sulfamoyl)naphthalene-1-yl)-3-methylbenzamide ([11C]5c), N-[11C]methyl-N-methyl-4-(4-benzamidonaphthalene-1-sulfonamido)piperidine-1-carboxamide ([11C]9a) and N-[11C]methyl-N-methyl-4-(4-(2-methylbenzamido)naphthalene-1-sulfonamido)piperidine-1-carboxamide ([11C]9b), have been synthesized as new potential positron emission tomography (PET) agents for imaging of human CCR8. The target tracers were prepared by either O-[11C]methylation or N-[11C]methylation of their corresponding precursors using [11C]CH3OTf and isolated by either a simplified solid-phase extraction (SPE) purification procedure or a high pressure liquid chromatography (HPLC) method in 30-50% radiochemical yields decay corrected to end of bombardment (EOB), 20-25 min overall synthesis time, and 74-111 GBq/μmol specific activity at end of synthesis (EOS).

Original languageEnglish
Pages (from-to)1406-1413
Number of pages8
JournalApplied Radiation and Isotopes
Volume66
Issue number10
DOIs
StatePublished - Oct 2008

Fingerprint

naphthalene
positrons
tomography
carbon
synthesis
methylation
piperidine
liquid chromatography
purification
tracers
solid phases
bombardment
decay

Keywords

  • Carbon-11
  • CC-chemokine receptor 8 (CCR8)
  • Imaging
  • Naphthalene-sulfonamides
  • Positron emission tomography (PET)

ASJC Scopus subject areas

  • Radiation

Cite this

Synthesis of new carbon-11 labeled naphthalene-sulfonamides for PET imaging of human CCR8. / Wang, Min; Cooley, Benjamin; Gao, Mingzhang; Miller, Kathy; Sledge, George W.; Hutchins, Gary; Zheng, Qi-Huang.

In: Applied Radiation and Isotopes, Vol. 66, No. 10, 10.2008, p. 1406-1413.

Research output: Contribution to journalArticle

Wang, Min ; Cooley, Benjamin ; Gao, Mingzhang ; Miller, Kathy ; Sledge, George W. ; Hutchins, Gary ; Zheng, Qi-Huang. / Synthesis of new carbon-11 labeled naphthalene-sulfonamides for PET imaging of human CCR8. In: Applied Radiation and Isotopes. 2008 ; Vol. 66, No. 10. pp. 1406-1413.
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