Carbon-11-labeled substituted Β-tetrahydrocarbolines were prepared from their corresponding phenolic hydroxyl precursors with [11C]CH3OTf through O-[11C]methylation and isolated by simplified SPE in 50-60& decay corrected radiochemical yields at EOB with 185-370GBq/μmol specific activity at EOS. A fluorine-18-labeled substituted Β-tetrahydrocarboline was prepared from its corresponding halo-precursors (X=Cl, Br, I) with K[18F]F/Kryptofix 2.2.2 via the nucleophilic substitution and isolated by HPLC combined with SPE in 25-40& decay corrected radiochemical yield with 37-222GBq/μmol specific activity at EOB.
- Neurological disorders
- Positron emission tomography (PET)
- Protein disulfide isomerase (PDI)
- Radiolabeled substituted Β-tetrahydrocarbolines
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