Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers

Mingzhang Gao, Min Wang, Kathy Miller, George W. Sledge, Gary Hutchins, Qi-Huang Zheng

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

New carbon-11 and fluorine-18 labeled stilbene derivatives, cis-3,5-dimethoxy-4′-[11C]methoxystilbene (4′-[11C]8a), cis-3,4′,5-trimethoxy-3′-[11C]methoxystilbene (3′-[11C]8b), trans-3,5-dimethoxy-4′-[11C]methoxystilbene (4′-[11C]10a), trans-3,4′,5-trimethoxy-3′-[11C]methoxystilbene (3′-[11C]10b), cis-3,5-dimethoxy-4′-[18F]fluorostilbene (4′-[18F]12a), and trans-3,5-dimethoxy-4′-[18F]fluorostilbene (4′-[18F]13a), were designed and synthesized as potential PET probes for aryl hydrocarbon receptor (AhR) in cancers.

Original languageEnglish
Pages (from-to)5767-5772
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number22
DOIs
StatePublished - Nov 15 2006

Fingerprint

Aryl Hydrocarbon Receptors
Stilbenes
Fluorine
Carbon
Derivatives
Neoplasms

Keywords

  • Aryl hydrocarbon receptor (AhR)
  • Cancer
  • Carbon-11
  • Fluorine-18
  • Positron emission tomography (PET)
  • Stilbene derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers. / Gao, Mingzhang; Wang, Min; Miller, Kathy; Sledge, George W.; Hutchins, Gary; Zheng, Qi-Huang.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 22, 15.11.2006, p. 5767-5772.

Research output: Contribution to journalArticle

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AU - Zheng, Qi-Huang

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