Synthesis of [18F]SU11248, a new potential PET tracer for imaging cancer tyrosine kinase

Ji Quan Wang, Kathy D. Miller, George W. Sledge, Qi Huang Zheng

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-[18F]fluoro-2-oxo-1, 2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, a new potential positron emission tomography tracer for imaging cancer tyrosine kinase, has been prepared by the nucleophilic substitution of the nitro-precursor N-[2-(diethylamino)ethyl]-5-[(Z)-(5-nitro-2-oxo-1,2-dihydro-3H- indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide with K 18F/Kryptofix 2.2.2 followed by a simple chromatography methodology combined solid-phase extraction with high-performance liquid chromatography purification procedures in 15-25% radiochemical yields.

Original languageEnglish (US)
Pages (from-to)4380-4384
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number19
DOIs
StatePublished - Oct 1 2005

Fingerprint

Pyrroles
Protein-Tyrosine Kinases
Imaging techniques
Positron emission tomography
Solid Phase Extraction
High performance liquid chromatography
Chromatography
Positron-Emission Tomography
Purification
Neoplasms
Substitution reactions
High Pressure Liquid Chromatography
sunitinib

Keywords

  • [F]SU11248
  • Cancer
  • Positron emission tomography
  • Synthesis
  • Tracer
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of [18F]SU11248, a new potential PET tracer for imaging cancer tyrosine kinase. / Wang, Ji Quan; Miller, Kathy D.; Sledge, George W.; Zheng, Qi Huang.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 19, 01.10.2005, p. 4380-4384.

Research output: Contribution to journalArticle

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AU - Zheng, Qi Huang

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AB - N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-[18F]fluoro-2-oxo-1, 2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, a new potential positron emission tomography tracer for imaging cancer tyrosine kinase, has been prepared by the nucleophilic substitution of the nitro-precursor N-[2-(diethylamino)ethyl]-5-[(Z)-(5-nitro-2-oxo-1,2-dihydro-3H- indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide with K 18F/Kryptofix 2.2.2 followed by a simple chromatography methodology combined solid-phase extraction with high-performance liquid chromatography purification procedures in 15-25% radiochemical yields.

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KW - Cancer

KW - Positron emission tomography

KW - Synthesis

KW - Tracer

KW - Tyrosine kinase

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