Systematic review of the relationship between early introduction of solid foods to infants and the development of allergic disease

Beth A. Tarini, Aaron Carroll, Colin M. Sox, Dimitri A. Christakis

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Objective: To assess the evidence that early solid feeding (before age 4 months) increases the risk of allergic disease. Data Sources: MEDLINE, the Cochrane Library, and the Drugs and Pharmacology section of EMBASE with key words "infant," "food," and "allergy." Study Selection: We found 2719 article citations and reviewed references of relevant articles. We critically evaluated the methods and results of articles that met inclusion criteria. We identified 13 studies that met inclusion criteria. There was only 1 controlled trial. Data Extraction: Allergic disease. Data Synthesis: Five studies found a positive association between early solid feeding and eczema, with a persistence of the association for 10 years in 1 study. Four studies found no association. One study found an association between early solid feeding and pollen allergy. We found no strong evidence to support the association between early solid feeding and the development of persistent asthma, persistent food allergy, allergic rhinitis, or animal dander allergy. Conclusions: Systematic review of available evidence suggests that early solid feeding may increase the risk of eczema. However, there are little data supporting an association between early solid feeding and other allergic conditions. Since many studies had problematic methods, additional controlled trials are needed to help guide physicians as they advise parents about the allergic risks of early introduction of solids.

Original languageEnglish
Pages (from-to)502-507
Number of pages6
JournalArchives of Pediatrics and Adolescent Medicine
Volume160
Issue number5
DOIs
StatePublished - May 2006

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Child Development
Food Hypersensitivity
Eczema
Food
Dander
Infant Food
Seasonal Allergic Rhinitis
Information Storage and Retrieval
MEDLINE
Libraries
Hypersensitivity
Asthma
Parents
Pharmacology
Physicians
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Systematic review of the relationship between early introduction of solid foods to infants and the development of allergic disease. / Tarini, Beth A.; Carroll, Aaron; Sox, Colin M.; Christakis, Dimitri A.

In: Archives of Pediatrics and Adolescent Medicine, Vol. 160, No. 5, 05.2006, p. 502-507.

Research output: Contribution to journalArticle

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