Systemic antibiotics and tooth loss in Periodontal disease

J. Cunha-Cruz, P. P. Hujoel, Gerardo Maupome, B. Saver

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Systemic antibiotics have been recommended for the treatment of destructive periodontal disease. Our goal was to relate antibiotic use for medical or dental reasons to subsequent tooth loss in a cohort of 12,631 persons with destructive periodontal disease. After adjustment for age, smoking, and other confounders, the dispensing of antibiotics for 1-13 days, 14-20 days, or 21 or more days was not associated with reduced tooth loss [Adjusted rate ratio (RR) = 1.0; 95% Confidence Interval (CI) = 0.8-1.1; RR = 1.2; 95% CI = 0.9-1.4, and RR =1.2, 95% CI =1.0-1.3, respectively]. Numerous subgroup analyses were consistent with these overall null findings, with two exceptions: Longer courses of tetracyclines were associated with reduced tooth loss among persons receiving periodontal care, and penicillin was associated with reduced tooth loss among persons with more severe disease. Long-term, larger randomized trials are needed to provide evidence that antibiotics reduce tooth loss when used in the management of destructive periodontal disease.

Original languageEnglish (US)
Pages (from-to)871-876
Number of pages6
JournalJournal of Dental Research
Volume87
Issue number9
DOIs
StatePublished - Sep 2008

Fingerprint

Tooth Loss
Periodontal Diseases
Anti-Bacterial Agents
Confidence Intervals
Tetracyclines
Penicillins
Tooth
Smoking

Keywords

  • Antimicrobials
  • Cohort study
  • Systemic antibiotics
  • Tooth loss

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Systemic antibiotics and tooth loss in Periodontal disease. / Cunha-Cruz, J.; Hujoel, P. P.; Maupome, Gerardo; Saver, B.

In: Journal of Dental Research, Vol. 87, No. 9, 09.2008, p. 871-876.

Research output: Contribution to journalArticle

Cunha-Cruz, J. ; Hujoel, P. P. ; Maupome, Gerardo ; Saver, B. / Systemic antibiotics and tooth loss in Periodontal disease. In: Journal of Dental Research. 2008 ; Vol. 87, No. 9. pp. 871-876.
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