T cell regulation of hematopoiesis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

It has long been known that thymus-derived lymphocytes (T cells) can produce cytokines that havepowerful effects on hematopoiesis. All major classes of T cells-CD4 T helper cells, CD4 regulatory T cells, CD8 T cells, γλ T cells and NKT cells-produce a number of cytokines and chemokines that can modulate hematopoiesis. More recent research has shown that specific T helper cell types, such as Th1, Th2 and Th17 cells, with the development of each subset depending ondistinct STAT proteins, have the potential to modulate the hematopoietic response in different ways. In a teleological sense, the overall orchestration of the immune response by T helper cells fits with the concept that T helper cellswould modulate the production of cells of the innate immune system by regulating hematopoiesis. Here we will review the literature on how T cell subsets regulatehematopoietic cell differentiation, and discuss how this regulation may complement the specific function of the T cell type.

Original languageEnglish
Pages (from-to)6229-6236
Number of pages8
JournalFrontiers in Bioscience
Volume13
Issue number16
StatePublished - May 1 2008

Fingerprint

T-cells
Hematopoiesis
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Cytokines
Th17 Cells
Th2 Cells
Th1 Cells
Natural Killer T-Cells
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Chemokines
Thymus Gland
Thymus
Cell Differentiation
Immune System
Lymphocytes
Immune system
Research
Proteins

Keywords

  • CD8
  • Cytokine
  • Inflammation
  • NKT
  • REview
  • T cell
  • Th1
  • Th17
  • Th2
  • Treg

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

T cell regulation of hematopoiesis. / Dent, Alexander; Kaplan, Mark.

In: Frontiers in Bioscience, Vol. 13, No. 16, 01.05.2008, p. 6229-6236.

Research output: Contribution to journalArticle

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