T cell responses during influenza infection: Getting and keeping control

Taeg S. Kim, Jie Sun, Thomas J. Braciale

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm of the adaptive host immune response to influenza. We assess recent developments in the understanding of how primary influenza virus-specific T cell responses are induced by antigen-presenting cells, the interaction of activated effector T cells with antigen-bearing cells in the infected lungs. Also examined is the contribution of influenza-specific effector T cells to the development and control of lung injury and inflammation during infection.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalTrends in Immunology
Volume32
Issue number5
DOIs
StatePublished - May 1 2011

Fingerprint

Human Influenza
T-Lymphocytes
Infection
Lung Injury
Adaptive Immunity
Pandemics
Antigen-Presenting Cells
Orthomyxoviridae
Cell Communication
Pneumonia
Viruses
Antigens
Lung
Health

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

T cell responses during influenza infection : Getting and keeping control. / Kim, Taeg S.; Sun, Jie; Braciale, Thomas J.

In: Trends in Immunology, Vol. 32, No. 5, 05.2011, p. 225-231.

Research output: Contribution to journalArticle

Kim, Taeg S. ; Sun, Jie ; Braciale, Thomas J. / T cell responses during influenza infection : Getting and keeping control. In: Trends in Immunology. 2011 ; Vol. 32, No. 5. pp. 225-231.
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