T helper cell subsets in the development of atopic dermatitis

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The pathogenesis of atopic dermatitis (AD) requires the orchestration of multiple immune cells that mediate inflammation and tissue remodeling in the skin. T helper cell subsets that secrete specific cytokines have a central role in regulating the inflammatory process. In this review we discuss defined roles for T helper subsets in AD, how the microbiome might impact the development and function of T helper subsets, and animal models that will be useful for testing hypotheses on the interactions of a polarized T-cell response with skin inflammation. Future studies that link these areas will provide important insight into the development of skin inflammation and AD.

Original languageEnglish (US)
Pages (from-to)1174-1178
Number of pages5
JournalJournal of Drugs in Dermatology
Volume11
Issue number10
StatePublished - Oct 1 2012

ASJC Scopus subject areas

  • Dermatology

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