T helper cell subsets in the development of atopic dermatitis

Matthew J. Turner, Jeffrey Travers, Mark Kaplan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The pathogenesis of atopic dermatitis (AD) requires the orchestration of multiple immune cells that mediate inflammation and tissue remodeling in the skin. T helper cell subsets that secrete specific cytokines have a central role in regulating the inflammatory process. In this review we discuss defined roles for T helper subsets in AD, how the microbiome might impact the development and function of T helper subsets, and animal models that will be useful for testing hypotheses on the interactions of a polarized T-cell response with skin inflammation. Future studies that link these areas will provide important insight into the development of skin inflammation and AD.

Original languageEnglish
Pages (from-to)1174-1178
Number of pages5
JournalJournal of drugs in dermatology : JDD
Volume11
Issue number10
StatePublished - Oct 2012

Fingerprint

T-Lymphocyte Subsets
Atopic Dermatitis
Inflammation
Skin
Microbiota
Animal Models
Cytokines
T-Lymphocytes

ASJC Scopus subject areas

  • Dermatology

Cite this

T helper cell subsets in the development of atopic dermatitis. / Turner, Matthew J.; Travers, Jeffrey; Kaplan, Mark.

In: Journal of drugs in dermatology : JDD, Vol. 11, No. 10, 10.2012, p. 1174-1178.

Research output: Contribution to journalArticle

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