Targeted Adenoviral Vectors III: Transcriptional Targeting

Sudhanshu P. Raikwar, Chinghai H. Kao, Thomas A. Gardner

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gene therapy is an innovative approach aimed to introducing genetic material into an organism for therapeutic intent. Still in its infancy, this novel concept has witnessed a fundamental preclinical success with numerous ongoing clinical trials to confirm these findings. Critical to the success of gene therapy trials are issues relating to specific delivery of physiologically active biomolecules at therapeutically significant concentrations. Initially this was achieved by using direct intralesional injections of vectors to localize the delivery to the target tissue and universal promoters to maximized expression at that site. Over the past several years we and several other investigators have investigated the potential of tumor-specific promoters to transcriptionally regulate gene expression in the laboratory and in clinical trials. The safety demonstrated by these trials using tumor/tissue-specific promoters has led to the recent approval of a trial administering a conditionally replicative adenovirus systemically for the treatment of metastatic prostate cancer.

Original languageEnglish (US)
Title of host publicationAdenoviral Vectors for Gene Therapy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages259-292
Number of pages34
ISBN (Print)9780128002766
DOIs
StatePublished - Apr 6 2016

Keywords

  • Oncolysis
  • Transcription
  • Transcriptional targeting
  • Tumor-specific promoters

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Raikwar, S. P., Kao, C. H., & Gardner, T. A. (2016). Targeted Adenoviral Vectors III: Transcriptional Targeting. In Adenoviral Vectors for Gene Therapy: Second Edition (pp. 259-292). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800276-6.00010-3