Targeting Angiogenesis and the Tumor Microenvironment

Jennifer Samples, Monte Willis, Nancy Klauber-DeMore

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the product of a crosstalk between different cells types. Active contribution of tumor-associated stromal cells to cancer progression has been recognized. Stromal elements consist of the extracellular matrix, fibroblasts of various phenotypes, and a scaffold comprised of immune and inflammatory cells, blood and lymph vessels, and nerves. This review focuses on therapeutic targets in the microenvironment related to tumor endothelium, tumor associated fibroblasts, and the extracellular matrix.

Original languageEnglish (US)
Pages (from-to)629-639
Number of pages11
JournalSurgical Oncology Clinics of North America
Volume22
Issue number4
DOIs
StatePublished - Oct 1 2013
Externally publishedYes

Fingerprint

Tumor Microenvironment
Extracellular Matrix
Neoplasms
Molecular Pathology
Lymph
Stromal Cells
Endothelium
Blood Vessels
Fibroblasts
Phenotype
Therapeutics

Keywords

  • Angiogenesis
  • Growth factors
  • Integrins
  • Tumor associated fibroblast
  • Tumor microenvironment

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Targeting Angiogenesis and the Tumor Microenvironment. / Samples, Jennifer; Willis, Monte; Klauber-DeMore, Nancy.

In: Surgical Oncology Clinics of North America, Vol. 22, No. 4, 01.10.2013, p. 629-639.

Research output: Contribution to journalReview article

Samples, Jennifer ; Willis, Monte ; Klauber-DeMore, Nancy. / Targeting Angiogenesis and the Tumor Microenvironment. In: Surgical Oncology Clinics of North America. 2013 ; Vol. 22, No. 4. pp. 629-639.
@article{b0bb3668f2f444d38992b105808a4886,
title = "Targeting Angiogenesis and the Tumor Microenvironment",
abstract = "The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the product of a crosstalk between different cells types. Active contribution of tumor-associated stromal cells to cancer progression has been recognized. Stromal elements consist of the extracellular matrix, fibroblasts of various phenotypes, and a scaffold comprised of immune and inflammatory cells, blood and lymph vessels, and nerves. This review focuses on therapeutic targets in the microenvironment related to tumor endothelium, tumor associated fibroblasts, and the extracellular matrix.",
keywords = "Angiogenesis, Growth factors, Integrins, Tumor associated fibroblast, Tumor microenvironment",
author = "Jennifer Samples and Monte Willis and Nancy Klauber-DeMore",
year = "2013",
month = "10",
day = "1",
doi = "10.1016/j.soc.2013.06.002",
language = "English (US)",
volume = "22",
pages = "629--639",
journal = "Surgical Oncology Clinics of North America",
issn = "1055-3207",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Targeting Angiogenesis and the Tumor Microenvironment

AU - Samples, Jennifer

AU - Willis, Monte

AU - Klauber-DeMore, Nancy

PY - 2013/10/1

Y1 - 2013/10/1

N2 - The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the product of a crosstalk between different cells types. Active contribution of tumor-associated stromal cells to cancer progression has been recognized. Stromal elements consist of the extracellular matrix, fibroblasts of various phenotypes, and a scaffold comprised of immune and inflammatory cells, blood and lymph vessels, and nerves. This review focuses on therapeutic targets in the microenvironment related to tumor endothelium, tumor associated fibroblasts, and the extracellular matrix.

AB - The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the product of a crosstalk between different cells types. Active contribution of tumor-associated stromal cells to cancer progression has been recognized. Stromal elements consist of the extracellular matrix, fibroblasts of various phenotypes, and a scaffold comprised of immune and inflammatory cells, blood and lymph vessels, and nerves. This review focuses on therapeutic targets in the microenvironment related to tumor endothelium, tumor associated fibroblasts, and the extracellular matrix.

KW - Angiogenesis

KW - Growth factors

KW - Integrins

KW - Tumor associated fibroblast

KW - Tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84883557142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883557142&partnerID=8YFLogxK

U2 - 10.1016/j.soc.2013.06.002

DO - 10.1016/j.soc.2013.06.002

M3 - Review article

C2 - 24012392

AN - SCOPUS:84883557142

VL - 22

SP - 629

EP - 639

JO - Surgical Oncology Clinics of North America

JF - Surgical Oncology Clinics of North America

SN - 1055-3207

IS - 4

ER -