Targeting Angiogenesis and the Tumor Microenvironment

Jennifer Samples, Monte Willis, Nancy Klauber-DeMore

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

The role of the microenvironment during the initiation and progression of malignancy is appreciated to be of critical importance for improved molecular diagnostics and therapeutics. The tumor microenvironment is the product of a crosstalk between different cells types. Active contribution of tumor-associated stromal cells to cancer progression has been recognized. Stromal elements consist of the extracellular matrix, fibroblasts of various phenotypes, and a scaffold comprised of immune and inflammatory cells, blood and lymph vessels, and nerves. This review focuses on therapeutic targets in the microenvironment related to tumor endothelium, tumor associated fibroblasts, and the extracellular matrix.

Original languageEnglish (US)
Pages (from-to)629-639
Number of pages11
JournalSurgical Oncology Clinics of North America
Volume22
Issue number4
DOIs
StatePublished - Oct 1 2013

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Keywords

  • Angiogenesis
  • Growth factors
  • Integrins
  • Tumor associated fibroblast
  • Tumor microenvironment

ASJC Scopus subject areas

  • Surgery
  • Oncology

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