Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells

Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J. Kotzin, Martin Carroll, Gerald Wertheim, Adam Williams, Sarath Chandra Janga, Chi Zhang, Jorge Henao-Mejia, Reuben Kapur

Research output: Contribution to journalArticlepeer-review

Abstract

Cai et al. report that MORRBID/Morrbid expression is aberrantly increased in human AML patients and mouse models for CMML, MPN, and AML. Genetic loss of Morrbid makes leukemic cells vulnerable to apoptosis and mitigates the progression of myeloid neoplasms. High expression of MORRBID in humans is associated with poor survival of AML patients.

Original languageEnglish (US)
Article number107816
JournalCell Reports
Volume31
Issue number12
DOIs
StatePublished - Jun 23 2020

Keywords

  • BIM
  • FLT3
  • MORRBID
  • TET2
  • apoptosis
  • leukemia
  • lncRNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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