Cai et al. report that MORRBID/Morrbid expression is aberrantly increased in human AML patients and mouse models for CMML, MPN, and AML. Genetic loss of Morrbid makes leukemic cells vulnerable to apoptosis and mitigates the progression of myeloid neoplasms. High expression of MORRBID in humans is associated with poor survival of AML patients.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)