Targeting Cancer Stemness in the Clinic: From Hype to Hope

Caner Saygin, Daniela Matei, Ravindra Majeti, Ofer Reizes, Justin D. Lathia

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Saygin et al. discuss the clinical significance of cancer stem cells (CSCs) and results of potential CSC-targeting therapies in various cancers. They highlight barriers to translating cues from pre-clinical models into clinical applications and propose new strategies for rational design of future anti-CSC trials.

Original languageEnglish (US)
Pages (from-to)25-40
Number of pages16
JournalCell Stem Cell
Volume24
Issue number1
DOIs
StatePublished - Jan 3 2019
Externally publishedYes

Fingerprint

Neoplastic Stem Cells
Neoplasms
Cell- and Tissue-Based Therapy
Cues

Keywords

  • cancer stem cell
  • CD123
  • differentiation therapies
  • hedgehog
  • niche
  • Notch

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

Targeting Cancer Stemness in the Clinic : From Hype to Hope. / Saygin, Caner; Matei, Daniela; Majeti, Ravindra; Reizes, Ofer; Lathia, Justin D.

In: Cell Stem Cell, Vol. 24, No. 1, 03.01.2019, p. 25-40.

Research output: Contribution to journalReview article

Saygin, C, Matei, D, Majeti, R, Reizes, O & Lathia, JD 2019, 'Targeting Cancer Stemness in the Clinic: From Hype to Hope', Cell Stem Cell, vol. 24, no. 1, pp. 25-40. https://doi.org/10.1016/j.stem.2018.11.017
Saygin, Caner ; Matei, Daniela ; Majeti, Ravindra ; Reizes, Ofer ; Lathia, Justin D. / Targeting Cancer Stemness in the Clinic : From Hype to Hope. In: Cell Stem Cell. 2019 ; Vol. 24, No. 1. pp. 25-40.
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