Targeting Cancer Stemness in the Clinic: From Hype to Hope

Caner Saygin, Daniela Matei, Ravindra Majeti, Ofer Reizes, Justin D. Lathia

Research output: Contribution to journalReview article

64 Scopus citations

Abstract

Saygin et al. discuss the clinical significance of cancer stem cells (CSCs) and results of potential CSC-targeting therapies in various cancers. They highlight barriers to translating cues from pre-clinical models into clinical applications and propose new strategies for rational design of future anti-CSC trials.

Original languageEnglish (US)
Pages (from-to)25-40
Number of pages16
JournalCell Stem Cell
Volume24
Issue number1
DOIs
StatePublished - Jan 3 2019
Externally publishedYes

Keywords

  • CD123
  • Notch
  • cancer stem cell
  • differentiation therapies
  • hedgehog
  • niche

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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