Targeting DNA repair pathways for cancer treatment: What's new?

Research output: Contribution to journalReview article

85 Scopus citations

Abstract

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A growing body of evidence indicates that tumors accumulate progressively more mutations in DNA repair proteins as cancers progress. DNA repair mechanisms greatly affect the response to cytotoxic treatments, so understanding those mechanisms and finding ways to turn dysregulated repair processes against themselves to induce tumor death is the goal of all DNA repair inhibition efforts. Inhibition may be direct or indirect. This burgeoning field of research is replete with promise and challenge, as more intricacies of each repair pathway are discovered. In an era of increasing concern about healthcare costs, use of DNA repair inhibitors can prove to be highly effective stewardship of R&D resources and patient expenses.

Original languageEnglish (US)
Pages (from-to)1215-1237
Number of pages23
JournalFuture Oncology
Volume10
Issue number7
DOIs
StatePublished - May 2014

Keywords

  • clinical trials
  • DNA repair inhibition
  • DNA repair pathways
  • DNA repair targets
  • small-molecule inhibitors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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