Targeting incretin hormones and the ASK-1 pathway as therapeutic options in the treatment of non-alcoholic steatohepatitis

Alexander J. Kovalic, Sanjaya K. Satapathy, Naga Chalasani

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Non-alcoholic fatty liver disease (NAFLD) is currently one of the leading forms of chronic liver disease, and its rising frequency worldwide has reached epidemic proportions. NAFLD, particularly its progressive variant NASH (non-alcoholic steatohepatitis), can lead to advanced fibrosis, cirrhosis, and HCC. The pathophysiologic mechanisms that contribute to the development and progression of NAFLD and NASH are complex, and as such myriad therapies are under investigation targeting different pathophysiological mechanisms. Incretin-based therapies, including GLP-1RAs and DPP-4 inhibitors and the inhibition of ASK1 pathway have provided two such novel mechanisms in the management of this disease, and will remain focus of this review.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalHepatology International
Volume12
Issue number2
DOIs
StatePublished - Mar 1 2018

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Keywords

  • ASK1
  • DPP-4
  • GLP-1
  • Incretin
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Hepatology

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