Targeting innate immunity for neurodegenerative disorders of the central nervous system

Katrin I. Andreasson, Adam D. Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C. Lee, Donovan Low, Marina A. Lynch, Alon Monsonego, M. Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A. Sandusky, Maj Linda B. Selenica, Kazuyuki Takata, Jessica Teeling, Terrence TownLinda J. Van Eldik

Research output: Contribution to journalReview article

66 Scopus citations

Abstract

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7–9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article. (Figure presented.) Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7–9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.

Original languageEnglish (US)
Pages (from-to)653-693
Number of pages41
JournalJournal of Neurochemistry
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Keywords

  • Alzheimer disease
  • Venusberg Neuroinflammation Meeting Bonn 2015
  • blood–brain barrier
  • innate immunity
  • macrophage
  • non-steroidal anti-inflammatory drugs (NSAIDs)

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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  • Cite this

    Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., Monsonego, A., O'Banion, M. K., Pekny, M., Puschmann, T., Russek-Blum, N., Sandusky, L. A., Selenica, M. L. B., Takata, K., Teeling, J., ... Van Eldik, L. J. (2016). Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of Neurochemistry, 653-693. https://doi.org/10.1111/jnc.13667