Targeting microenvironment in cancer therapeutics

Matthew Martin, Han Wei, Tao Lu

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

During development of a novel treatment for cancer patients, the tumor microenvironment and its interaction with the tumor cells must be considered. Aspects such as the extracellular matrix (ECM), the epithelial-mesenchymal transition (EMT), secreted factors, cancer-associated fibroblasts (CAFs), the host immune response, and tumor-associated microphages (TAM) are critical for cancer progression and metastasis. Additionally, signaling pathways such as the nuclear factor κB (NF- κB), transforming growth factor β (TGFβ), and tumor necrosis factor α (TNFα) can promote further cytokine release in the tumor environment, and impact tumor progression greatly. Importantly, cytokine overexpression has been linked to drug resistance in cancers and is therefore an attractive target for combinational therapies. Specific inhibitors of cytokines involved in signaling between tumor cells and the microenvironment have not been studied in depth and have great potential for use in personalized medicines. Together, the interactions between the microenvironment and tumors are critical for tumor growth and promotion and should be taken into serious consideration for future novel therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)52575-52583
Number of pages9
JournalOncotarget
Volume7
Issue number32
DOIs
StatePublished - Aug 1 2016

Fingerprint

Tumor Microenvironment
Neoplasms
Therapeutics
Cytokines
Cellular Microenvironment
Precision Medicine
Epithelial-Mesenchymal Transition
Transforming Growth Factors
Drug Resistance
Extracellular Matrix
Tumor Necrosis Factor-alpha
Neoplasm Metastasis
Growth

Keywords

  • Cancer
  • Cytokine
  • Microenvironment
  • Transcription factor

ASJC Scopus subject areas

  • Oncology

Cite this

Targeting microenvironment in cancer therapeutics. / Martin, Matthew; Wei, Han; Lu, Tao.

In: Oncotarget, Vol. 7, No. 32, 01.08.2016, p. 52575-52583.

Research output: Contribution to journalReview article

Martin, Matthew ; Wei, Han ; Lu, Tao. / Targeting microenvironment in cancer therapeutics. In: Oncotarget. 2016 ; Vol. 7, No. 32. pp. 52575-52583.
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