Targeting proteins to membranes using signal sequences for lipid modification

Patricia A. Solski, Lawrence A. Quilliam, Sarah G. Coats, Channing J. Der, Janice E. Buss

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Covalent attachment of lipids appears to be an important mechanism by which many proteins interact with membranes. As we learn more about how lipids and adjacent amino acids participate in addressing proteins to specific membranes within the cell, it should be possible to design more elegant and precise membrane targeting systems that can be used to guide proteins to functionally relevant destinations.

Original languageEnglish (US)
Pages (from-to)435-454
Number of pages20
JournalMethods in Enzymology
Volume250
Issue numberC
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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