Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L)

Characterizing the interactions between dot1l and mixed lineage leukemia (MLL) fusion proteins

Chenxi Shen, Stephanie Y. Jo, Chenzhong Liao, Jay Hess, Zaneta Nikolovska-Coleska

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: MLL fusion proteins use similar strategy for leukemic transformation through DOT1L recruitment. Results: Ten amino acids in DOT1L were identified as essential for binding and transformation by MLL-AF9. Conclusion: Biochemical and functional results indicate that blocking DOT1L recruitment represents a promising therapeutic strategy for mixed lineage leukemia. Significance: Identified DOT1L peptide will lay a foundation toward discovery of chemical tools able to block DOT1L recruitment.

Original languageEnglish (US)
Pages (from-to)30585-30596
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013
Externally publishedYes

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Myeloid-Lymphoid Leukemia Protein
Leukemia
Fusion reactions
Amino Acids
Peptides
Proteins
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L) : Characterizing the interactions between dot1l and mixed lineage leukemia (MLL) fusion proteins. / Shen, Chenxi; Jo, Stephanie Y.; Liao, Chenzhong; Hess, Jay; Nikolovska-Coleska, Zaneta.

In: Journal of Biological Chemistry, Vol. 288, No. 42, 18.10.2013, p. 30585-30596.

Research output: Contribution to journalArticle

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