Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): Characterizing the interactions between dot1l and mixed lineage leukemia (MLL) fusion proteins

Chenxi Shen, Stephanie Y. Jo, Chenzhong Liao, Jay L. Hess, Zaneta Nikolovska-Coleska

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Background: MLL fusion proteins use similar strategy for leukemic transformation through DOT1L recruitment. Results: Ten amino acids in DOT1L were identified as essential for binding and transformation by MLL-AF9. Conclusion: Biochemical and functional results indicate that blocking DOT1L recruitment represents a promising therapeutic strategy for mixed lineage leukemia. Significance: Identified DOT1L peptide will lay a foundation toward discovery of chemical tools able to block DOT1L recruitment.

Original languageEnglish (US)
Pages (from-to)30585-30596
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number42
DOIs
StatePublished - Oct 18 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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