Targeting the bone microenvironment in multiple myeloma

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Multiple myeloma (MM) is a plasma cell malignancy characterized by the frequent development of osteolytic lesions, osteopenia, pathological fractures, and/or severe bone pain. In the past few years several potential factors involved in this process have been identified and, with the increased knowledge of the signaling pathways involved in the regulation of normal osteoblast and osteoclast function, have provided us with a better understanding of the contributions of the marrow microenvironment to MM bone disease. These studies have identified several potential novel targets for treating MM bone disease in addition to the current standard treatment of bisphosphonates. In this article, we discuss several potential targets for treating MM bone disease as well as novel therapies that are in clinical trials for these patients.

Original languageEnglish (US)
Pages (from-to)244-250
Number of pages7
JournalJournal of Bone and Mineral Metabolism
Volume28
Issue number3
DOIs
StatePublished - May 1 2010
Externally publishedYes

Keywords

  • Bisphosphonates
  • Bone microenvironment
  • Cytokines
  • Multiple myeloma
  • Osteoclast

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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