This chapter discusses the nucleotide excision repair pathway (NER) for therapeutic applications. The NER pathway involves a complex series of reactions and interactions that lead to the effective removal of damage from DNA and is crucial in maintaining genome integrity and stability. The role of NER in removing cisplatin chemotherapy-induced DNA damage and the demonstrated mechanism of resistance in multiple cancers involving increased repair presents the opportunity for intervention. Realization of this potential to sensitize cancers to cisplatin and reverse resistance of those cancers that develop insensitivity to this agent will require the development of specific agents capable of targeting the NER pathway. The possibility exists that the success of platinum therapy in the treatment of testicular cancer can be replicated in lung and ovarian cancers where the lack of response to platinum therapy is a major determinant of the dismal survival statistics associated with those diseases. Such a finding would be a watershed event that could dramatically alter treatments of human cancer.
|Original language||English (US)|
|Title of host publication||DNA Repair in Cancer Therapy|
|Number of pages||9|
|State||Published - Dec 1 2012|
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