Task-evoked functional connectivity does not explain functional connectivity differences between rest and task conditions

Lauren K. Lynch, Kun Han Lu, Haiguang Wen, Yizhen Zhang, Andrew J. Saykin, Zhongming Liu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task state and the resting state may reflect not only task-evoked functional connectivity, but also changes in spontaneously emerging networks. Here, we characterized the differences in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally explained by the task-evoked functional connectivity involved in processing the movie content. Instead, they were mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non-visual sensory or motor cortices. Our results suggest that task-evoked activity is not independent from spontaneous activity, and that engaging in a task may suppress spontaneous activity and its inter-regional correlation.

Original languageEnglish (US)
Pages (from-to)4939-4948
Number of pages10
JournalHuman Brain Mapping
Volume39
Issue number12
DOIs
StatePublished - Dec 2018

    Fingerprint

Keywords

  • natural vision
  • spontaneous activity
  • task evoked functional connectivity
  • task–rest interaction

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this