Tasquinimod targets suppressive myeloid cells in the tumor microenvironment

Li Shen, Roberto Pili

Research output: Contribution to journalArticle

Abstract

Infiltrating myeloid derived suppressor cells and tumor-associated macrophages (TAMs) are important components of the immunosuppressive tumor microenvironment. We recently reported that tasquinimod, which binds to S100A9, impairs both infiltration and function of these cells. Here we discuss the underlying mechanisms responsible for targeting multiple suppressive populations and the modulation of the tumor microenvironment.

Original languageEnglish (US)
Article numbere1072672
JournalOncoImmunology
Volume8
Issue number10
DOIs
StatePublished - Jan 1 2019

Keywords

  • S100A9
  • Tasquinimod
  • immunotherapy
  • myeloid-derived suppressor cells (MDSCs)
  • suppressive myeloid cells (SMCs)
  • tumor associated macrophages (TAMs)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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