Tasquinimod targets suppressive myeloid cells in the tumor microenvironment

Li Shen, Roberto Pili

Research output: Contribution to journalArticle

Abstract

Infiltrating myeloid derived suppressor cells and tumor-associated macrophages (TAMs) are important components of the immunosuppressive tumor microenvironment. We recently reported that tasquinimod, which binds to S100A9, impairs both infiltration and function of these cells. Here we discuss the underlying mechanisms responsible for targeting multiple suppressive populations and the modulation of the tumor microenvironment.

Original languageEnglish (US)
JournalOncoImmunology
DOIs
StateAccepted/In press - May 3 2018

Fingerprint

Tumor Microenvironment
Myeloid Cells
Immunosuppressive Agents
Macrophages
Population
Neoplasms
tasquinimod
Myeloid-Derived Suppressor Cells

Keywords

  • immunotherapy
  • myeloid-derived suppressor cells (MDSCs)
  • S100A9
  • suppressive myeloid cells (SMCs)
  • Tasquinimod
  • tumor associated macrophages (TAMs)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this

Tasquinimod targets suppressive myeloid cells in the tumor microenvironment. / Shen, Li; Pili, Roberto.

In: OncoImmunology, 03.05.2018.

Research output: Contribution to journalArticle

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