Tear me down: Role of calpain in the development of cardiac ventricular hypertrophy

Cam Patterson, Andrea L. Portbury, Jonathan C. Schisler, Monte S. Willis

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Cardiac hypertrophy develops most commonly in response to hypertension and is an independent risk factor for the development of heart failure. The mechanisms by which cardiac hypertrophy may be reversed to reduce this risk have not been fully determined to the point where mechanism-specific therapies have been developed. Recently, proteases in the calpain family have been implicated in the regulation of the development of cardiac hypertrophy in preclinical animal models. In this review, we summarize the molecular mechanisms by which calpain inhibition has been shown to modulate the development of cardiac (specifically ventricular) hypertrophy. The context within which calpain inhibition might be developed for therapeutic intervention of cardiac hypertrophy is then discussed.

Original languageEnglish (US)
Pages (from-to)453-462
Number of pages10
JournalCirculation research
Volume109
Issue number4
DOIs
StatePublished - Aug 5 2011

Keywords

  • HSP90 heat-shock proteins
  • NF-κB inhibition
  • calpain
  • calpastatin
  • cardiac hypertrophy
  • β3 integrin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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