Tearin' up my heart: Proteolysis in the cardiac sarcomere

Andrea L. Portbury, Monte S. Willis, Cam Patterson

Research output: Contribution to journalShort survey

63 Scopus citations


Proteolysis within the cardiac sarcomere is a constantly evolving area of research. Three major pathways of proteolysis have been identified as being active within the cardiac sarcomere, namely the ubiquitin-proteasome system, autophagy, and the calpain system. The role of ubiquitin-proteasome system-mediated proteolysis in cardiovascular health and disease has been known for some time; however, it is now apparent that other proteolytic systems also aid in the stabilization of cardiac sarcomere structure and function. This minireview focuses on the individual as well as cooperative involvement of each of these three major pathways of proteolysis within the cardiac sarcomere.

Original languageEnglish (US)
Pages (from-to)9929-9934
Number of pages6
JournalJournal of Biological Chemistry
Issue number12
StatePublished - Mar 25 2011

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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