Tearin' up my heart: Proteolysis in the cardiac sarcomere

Andrea L. Portbury, Monte Willis, Cam Patterson

Research output: Contribution to journalShort survey

60 Citations (Scopus)

Abstract

Proteolysis within the cardiac sarcomere is a constantly evolving area of research. Three major pathways of proteolysis have been identified as being active within the cardiac sarcomere, namely the ubiquitin-proteasome system, autophagy, and the calpain system. The role of ubiquitin-proteasome system-mediated proteolysis in cardiovascular health and disease has been known for some time; however, it is now apparent that other proteolytic systems also aid in the stabilization of cardiac sarcomere structure and function. This minireview focuses on the individual as well as cooperative involvement of each of these three major pathways of proteolysis within the cardiac sarcomere.

Original languageEnglish (US)
Pages (from-to)9929-9934
Number of pages6
JournalJournal of Biological Chemistry
Volume286
Issue number12
DOIs
StatePublished - Mar 25 2011
Externally publishedYes

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Proteolysis
Sarcomeres
Proteasome Endopeptidase Complex
Ubiquitin
Calpain
Autophagy
Cardiovascular Diseases
Stabilization
Health
Research

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Tearin' up my heart : Proteolysis in the cardiac sarcomere. / Portbury, Andrea L.; Willis, Monte; Patterson, Cam.

In: Journal of Biological Chemistry, Vol. 286, No. 12, 25.03.2011, p. 9929-9934.

Research output: Contribution to journalShort survey

Portbury, Andrea L. ; Willis, Monte ; Patterson, Cam. / Tearin' up my heart : Proteolysis in the cardiac sarcomere. In: Journal of Biological Chemistry. 2011 ; Vol. 286, No. 12. pp. 9929-9934.
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