Technical advancements and protocol optimization of diffusion-weighted imaging (DWI) in liver

Ping Ni, Yuning Lin, Qun Zhong, Ziqian Chen, Kumar Sandrasegaran, Chen Lin

Research output: Contribution to journalArticle

7 Scopus citations


An area of rapid advancement in abdominal MRI is diffusion-weighted imaging (DWI). By measuring diffusion properties of water molecules, DWI is capable of non-invasively probing tissue properties and physiology at cellular and macromolecular level. The integration of DWI as part of abdominal MRI exam allows better lesion characterization and therefore more accurate initial diagnosis and treatment monitoring. One of the most technical challenging, but also most useful abdominal DWI applications is in liver and therefore requires special attention and careful optimization. In this article, the latest technical developments of DWI and its liver applications are reviewed with the explanations of the technical principles, recommendations of the imaging parameters, and examples of clinical applications. More advanced DWI techniques, including Intra-Voxel Incoherent Motion (IVIM) diffusion imaging, anomalous diffusion imaging, and Diffusion Kurtosis Imaging (DKI) are discussed.

Original languageEnglish (US)
Pages (from-to)189-202
Number of pages14
JournalAbdominal Radiology
Issue number1
StatePublished - Jan 1 2016


  • Anomalous diffusion
  • Diffusion kurtosis
  • Intra-voxel incoherent motion diffusion
  • Liver diffusion weighted imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology
  • Radiological and Ultrasound Technology

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