Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats

An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers

Shenghong Ju, Gordon McLennan, Stacy L. Bennett, Yun Liang, Laurent Bonnac, Krzysztof W. Pankiewicz, Hiremagalur N. Jayaram

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging techniques that can be used on tumors in rats. A total of 106 N1-S1 cells were inoculated into the left lobes of 74 rats. In 17, transfemoral angiography was attempted. Tumor volumes for 2 weeks before angiography were measured with magnetic resonance imaging in 40 animals. Tumors grew in 63 animals. Angiography was successful in 16 rats. Mean tumor volumes were 0.13 mL and 0.9 mL after 1 and 2 weeks, respectively. In conclusion, transfemoral hepatic artery catheterization is feasible in this animal model.

Original languageEnglish
Pages (from-to)410-414
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume20
Issue number3
DOIs
StatePublished - Mar 2009

Fingerprint

Liver Neoplasms
Angiography
Hepatic Artery
Tumor Burden
Catheterization
Neoplasms
Therapeutics
Animal Models
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats : An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers. / Ju, Shenghong; McLennan, Gordon; Bennett, Stacy L.; Liang, Yun; Bonnac, Laurent; Pankiewicz, Krzysztof W.; Jayaram, Hiremagalur N.

In: Journal of Vascular and Interventional Radiology, Vol. 20, No. 3, 03.2009, p. 410-414.

Research output: Contribution to journalArticle

@article{fab2af93f4204f5a8f267f27f11760fc,
title = "Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats: An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers",
abstract = "The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging techniques that can be used on tumors in rats. A total of 106 N1-S1 cells were inoculated into the left lobes of 74 rats. In 17, transfemoral angiography was attempted. Tumor volumes for 2 weeks before angiography were measured with magnetic resonance imaging in 40 animals. Tumors grew in 63 animals. Angiography was successful in 16 rats. Mean tumor volumes were 0.13 mL and 0.9 mL after 1 and 2 weeks, respectively. In conclusion, transfemoral hepatic artery catheterization is feasible in this animal model.",
author = "Shenghong Ju and Gordon McLennan and Bennett, {Stacy L.} and Yun Liang and Laurent Bonnac and Pankiewicz, {Krzysztof W.} and Jayaram, {Hiremagalur N.}",
year = "2009",
month = "3",
doi = "10.1016/j.jvir.2008.12.408",
language = "English",
volume = "20",
pages = "410--414",
journal = "Journal of Vascular and Interventional Radiology",
issn = "1051-0443",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats

T2 - An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers

AU - Ju, Shenghong

AU - McLennan, Gordon

AU - Bennett, Stacy L.

AU - Liang, Yun

AU - Bonnac, Laurent

AU - Pankiewicz, Krzysztof W.

AU - Jayaram, Hiremagalur N.

PY - 2009/3

Y1 - 2009/3

N2 - The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging techniques that can be used on tumors in rats. A total of 106 N1-S1 cells were inoculated into the left lobes of 74 rats. In 17, transfemoral angiography was attempted. Tumor volumes for 2 weeks before angiography were measured with magnetic resonance imaging in 40 animals. Tumors grew in 63 animals. Angiography was successful in 16 rats. Mean tumor volumes were 0.13 mL and 0.9 mL after 1 and 2 weeks, respectively. In conclusion, transfemoral hepatic artery catheterization is feasible in this animal model.

AB - The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging techniques that can be used on tumors in rats. A total of 106 N1-S1 cells were inoculated into the left lobes of 74 rats. In 17, transfemoral angiography was attempted. Tumor volumes for 2 weeks before angiography were measured with magnetic resonance imaging in 40 animals. Tumors grew in 63 animals. Angiography was successful in 16 rats. Mean tumor volumes were 0.13 mL and 0.9 mL after 1 and 2 weeks, respectively. In conclusion, transfemoral hepatic artery catheterization is feasible in this animal model.

UR - http://www.scopus.com/inward/record.url?scp=60649091879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60649091879&partnerID=8YFLogxK

U2 - 10.1016/j.jvir.2008.12.408

DO - 10.1016/j.jvir.2008.12.408

M3 - Article

VL - 20

SP - 410

EP - 414

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 3

ER -