TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9- 6/CCR9 as a specific receptor

Byung S. Youn, Chang H. Kim, Franklin O. Smith, Hal Broxmeyer

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Chemokines regulate leukocytes trafficking in normal and inflammation conditions. Thymus-seeding progenitors are made in bone marrow and migrate to the thymus where they undergo their maturation to antigen-specific T cells. Immature T cells are in thymic cortex, while mature thymocytes are in medulla. Chemokines may be important for homing of thymus-seeding progenitors, and/or differential thymocyte localization in thymus. Here we report that GPR-9-6, now called CC chemokine receptor 9 (CCR9), is a receptor for thymus-expressed chemokine, TECK. Among a panel of chemokines tested, TECK specifically induced calcium flux in CCR9-expressing cell lines. We also showed that TECK efficaciously induced chemotaxis of immature CD4+CD8+ double-positive, and mature CD4+ and CD8+ single-positive human thymocytes. Our data suggest that TECK/CCR9 interaction may play a pivotal role in T-cell migration in the thymus.

Original languageEnglish (US)
Pages (from-to)2533-2536
Number of pages4
JournalBlood
Volume94
Issue number7
StatePublished - Oct 1 1999
Externally publishedYes

Fingerprint

Ground penetrating radar systems
Thymus
Chemotactic Factors
Thymocytes
Thymus Gland
Chemokines
T-cells
T-Lymphocytes
Chemotaxis
Cell Movement
CC chemokine receptor 9
Bone
Leukocytes
Bone Marrow
Cells
Fluxes
Inflammation
Calcium
Antigens
Cell Line

ASJC Scopus subject areas

  • Hematology

Cite this

TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9- 6/CCR9 as a specific receptor. / Youn, Byung S.; Kim, Chang H.; Smith, Franklin O.; Broxmeyer, Hal.

In: Blood, Vol. 94, No. 7, 01.10.1999, p. 2533-2536.

Research output: Contribution to journalArticle

Youn, Byung S. ; Kim, Chang H. ; Smith, Franklin O. ; Broxmeyer, Hal. / TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9- 6/CCR9 as a specific receptor. In: Blood. 1999 ; Vol. 94, No. 7. pp. 2533-2536.
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