Telomere length associations with cognition depend on Alzheimer's disease biomarkers

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

Abstract

Introduction: While telomere shortening, a marker of cellular aging, may impact the progression of age-related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Methods: Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measured by memory and executive function) and interactions with CSF amyloid-β, tau, and APOE-ε4. Secondary analyses assessed brain volume and thickness outcomes. Results: Longer telomeres at baseline were associated with faster executive function decline. Amyloid-β and tau interacted with telomere length on cognition, with longer telomeres related to faster decline among biomarker-positive individuals. Discussion: Telomere associations with cognition shift with AD progression, with longer telomeres related to worse outcomes as pathology increases, highlighting the need for further investigation of telomere length along the AD neuropathological cascade.

Original languageEnglish (US)
Pages (from-to)883-890
Number of pages8
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume5
DOIs
StatePublished - 2019

Fingerprint

Telomere
Cognition
Alzheimer Disease
Biomarkers
Executive Function
Amyloid
Pathology
Telomere Shortening
Cell Aging
Neuroimaging
Neurodegenerative Diseases
Disease Progression
Brain

Keywords

  • APOE
  • Cognition
  • CSF biomarkers
  • Executive function
  • Telomeres

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Telomere length associations with cognition depend on Alzheimer's disease biomarkers. / Alzheimer's Disease Neuroimaging Initiative.

In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 5, 2019, p. 883-890.

Research output: Contribution to journalArticle

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author = "{Alzheimer's Disease Neuroimaging Initiative} and Mahoney, {Emily R.} and Logan Dumitrescu and Mabel Seto and Nudelman, {Kelly N.H.} and Buckley, {Rachel F.} and Gifford, {Katie A.} and Saykin, {Andrew J.} and Jefferson, {Angela J.} and Hohman, {Timothy J.}",
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AU - Mahoney, Emily R.

AU - Dumitrescu, Logan

AU - Seto, Mabel

AU - Nudelman, Kelly N.H.

AU - Buckley, Rachel F.

AU - Gifford, Katie A.

AU - Saykin, Andrew J.

AU - Jefferson, Angela J.

AU - Hohman, Timothy J.

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N2 - Introduction: While telomere shortening, a marker of cellular aging, may impact the progression of age-related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Methods: Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measured by memory and executive function) and interactions with CSF amyloid-β, tau, and APOE-ε4. Secondary analyses assessed brain volume and thickness outcomes. Results: Longer telomeres at baseline were associated with faster executive function decline. Amyloid-β and tau interacted with telomere length on cognition, with longer telomeres related to faster decline among biomarker-positive individuals. Discussion: Telomere associations with cognition shift with AD progression, with longer telomeres related to worse outcomes as pathology increases, highlighting the need for further investigation of telomere length along the AD neuropathological cascade.

AB - Introduction: While telomere shortening, a marker of cellular aging, may impact the progression of age-related neurodegenerative diseases, its association with cognition is unclear, particularly in the context of Alzheimer's disease (AD) pathology. Methods: Telomere, cognitive, and CSF data from 482 participants in the AD Neuroimaging Initiative (148 cognitively normal, 283 mild cognitive impairment, 51 AD) was leveraged to assess telomere length associations with cognition (measured by memory and executive function) and interactions with CSF amyloid-β, tau, and APOE-ε4. Secondary analyses assessed brain volume and thickness outcomes. Results: Longer telomeres at baseline were associated with faster executive function decline. Amyloid-β and tau interacted with telomere length on cognition, with longer telomeres related to faster decline among biomarker-positive individuals. Discussion: Telomere associations with cognition shift with AD progression, with longer telomeres related to worse outcomes as pathology increases, highlighting the need for further investigation of telomere length along the AD neuropathological cascade.

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