Telomere shortening distinguishes inverted urothelial neoplasms

Sean R. Williamson, Shaobo Zhang, Antonio Lopez-Beltran, Rodolfo Montironi, Mingsheng Wang, Liang Cheng

Research output: Contribution to journalArticle

9 Scopus citations


Aims: To investigate relative telomere length in inverted urothelial neoplasms, including inverted papilloma and urothelial carcinoma with an inverted growth pattern. Telomere shortening has been implicated as an early event in the development of epithelial malignancies in a number of organ systems. Methods and results: Formalin-fixed, paraffin-embedded tissue sections from 77 cases were studied, including 26 cases of inverted papilloma, 26 urothelial carcinomas with inverted growth, and 25 cases of cystitis glandularis. Quantitative fluorescence in-situ hybridization (FISH) was performed on interphase nuclei, utilizing a telomere-specific peptide nucleic acid probe to assess telomeric signal intensity. Relative telomere lengths for urothelial carcinoma with inverted growth, cystitis glandularis and inverted papilloma were 29%, 84%, and 91%, respectively. A statistically significant reduction in relative telomere length was present between urothelial carcinoma with inverted growth and inverted papilloma (P < 0.001); no significant difference was detected between normal urothelium, cystitis glandularis, and inverted papilloma. Conclusions: Significant telomere shortening in urothelial carcinoma with inverted growth as compared with inverted papilloma distinguishes the two lesions, and supports the notion that inverted papilloma is a benign neoplasm with a distinct pathogenetic mechanism of development. Telomeric FISH analysis may be a useful biomarker in distinguishing inverted papilloma from urothelial carcinoma with inverted growth.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
Issue number4
StatePublished - Mar 1 2013


  • Biomarker
  • Cystitis glandularis
  • Fluorescence in-situ hybridization (FISH)
  • Inverted papilloma
  • Telomere
  • Urinary bladder
  • Urothelial carcinoma with inverted growth

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

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