Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: A multimethod association study

Elizabeth P. Hayden, Lea R. Dougherty, Bryan Maloney, C. Emily Durbin, Thomas M. Olino, John Nurnberger, Debomoy Lahiri, Daniel N. Klein

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

OBJECTIVES: Early-emerging, temperamental differences in fear-related traits may be a heritable vulnerability factor for anxiety disorders. Previous research indicates that the serotonin transporter promoter region polymorphism is a candidate gene for such traits. METHODS: Associations between 5-HTTLPR genotype and indices of fearful child temperament, derived from maternal report and standardized laboratory observations, were examined in a community sample of 95 preschool-aged children. RESULTS: Children with one or more long alleles of the 5-HTTLPR gene were rated as significantly more nervous during standardized laboratory tasks than children who were homozygous for the short alleles. Children homozygous for the short alleles were also rated as significantly shyer, by maternal report, than those with at least one copy of the long allele of the 5-HTTLPR gene. CONCLUSIONS: This study extends the literature linking the short alleles of the serotonin transporter promoter region polymorphism to fear and anxiety-related traits in early childhood and adulthood, and is one of very few studies to examine the molecular genetics of preschoolers' temperament using multiple measures of traits in a normative sample.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalPsychiatric Genetics
Volume17
Issue number3
DOIs
StatePublished - Jun 2007

Fingerprint

Serotonin Plasma Membrane Transport Proteins
Genetic Promoter Regions
Alleles
Temperament
Fear
Mothers
Genes
Preschool Children
Anxiety Disorders
Molecular Biology
Anxiety
Genotype
Research

Keywords

  • 5-HTT promoter
  • Fear
  • Serotonin transporter gene
  • Single nucleotide polymorphism
  • Temperament

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

Cite this

Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism : A multimethod association study. / Hayden, Elizabeth P.; Dougherty, Lea R.; Maloney, Bryan; Emily Durbin, C.; Olino, Thomas M.; Nurnberger, John; Lahiri, Debomoy; Klein, Daniel N.

In: Psychiatric Genetics, Vol. 17, No. 3, 06.2007, p. 135-142.

Research output: Contribution to journalArticle

Hayden, Elizabeth P. ; Dougherty, Lea R. ; Maloney, Bryan ; Emily Durbin, C. ; Olino, Thomas M. ; Nurnberger, John ; Lahiri, Debomoy ; Klein, Daniel N. / Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism : A multimethod association study. In: Psychiatric Genetics. 2007 ; Vol. 17, No. 3. pp. 135-142.
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