Temporal lobe abnormalities in a patient with schizophrenia who has word-finding difficulty: Use of high-resolution magnetic resonance imaging and auditory p300 event-related potentials

Martha E. Shenton, Brian F. O'Donnell, Paul G. Nestor, Cynthia G. Wible, Ron Kikinis, Steven F. Faux, Seth D. Pollak, Ferenc A. Jolesz, Robert W. Mccarley

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Postmortem, magnetic resonance, and event-related potential studies suggest the presence of temporal lobe abnormalities in schizophrenia. Analyses using convergent measurements of brain structure and function, however, have rarely been done in the same patients. We recently developed a protocol using high-spatial-resolution magnetic resonance scans, auditory P300 event-related potentials, and thought disorder scales to examine temporal lobe structure and function in the same patients. We report a case of schizophrenia that showed left-lateralized volume reduction in the superior temporal gyrus, hippocampus, and parahippocampal gyrus (also on right), with associated P300 amplitude reduction and thought disorder marked by word-finding difficulties and perseverations.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalHarvard Review of Psychiatry
Volume1
Issue number2
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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