Temporal lobe abnormalities in a patient with schizophrenia who has word-finding difficulty: Use of high-resolution magnetic resonance imaging and auditory p300 event-related potentials

Martha E. Shenton, Brian O'Donnell, Paul G. Nestor, Cynthia G. Wible, Ron Kikinis, Steven F. Faux, Seth D. Pollak, Ferenc A. Jolesz, Robert W. Mccarley

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Postmortem, magnetic resonance, and event-related potential studies suggest the presence of temporal lobe abnormalities in schizophrenia. Analyses using convergent measurements of brain structure and function, however, have rarely been done in the same patients. We recently developed a protocol using high-spatial-resolution magnetic resonance scans, auditory P300 event-related potentials, and thought disorder scales to examine temporal lobe structure and function in the same patients. We report a case of schizophrenia that showed left-lateralized volume reduction in the superior temporal gyrus, hippocampus, and parahippocampal gyrus (also on right), with associated P300 amplitude reduction and thought disorder marked by word-finding difficulties and perseverations.

Original languageEnglish (US)
Pages (from-to)110-117
Number of pages8
JournalHarvard Review of Psychiatry
Volume1
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

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P300 Event-Related Potentials
Temporal Lobe
Schizophrenia
Parahippocampal Gyrus
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Evoked Potentials
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Temporal lobe abnormalities in a patient with schizophrenia who has word-finding difficulty : Use of high-resolution magnetic resonance imaging and auditory p300 event-related potentials. / Shenton, Martha E.; O'Donnell, Brian; Nestor, Paul G.; Wible, Cynthia G.; Kikinis, Ron; Faux, Steven F.; Pollak, Seth D.; Jolesz, Ferenc A.; Mccarley, Robert W.

In: Harvard Review of Psychiatry, Vol. 1, No. 2, 1993, p. 110-117.

Research output: Contribution to journalArticle

Shenton, Martha E. ; O'Donnell, Brian ; Nestor, Paul G. ; Wible, Cynthia G. ; Kikinis, Ron ; Faux, Steven F. ; Pollak, Seth D. ; Jolesz, Ferenc A. ; Mccarley, Robert W. / Temporal lobe abnormalities in a patient with schizophrenia who has word-finding difficulty : Use of high-resolution magnetic resonance imaging and auditory p300 event-related potentials. In: Harvard Review of Psychiatry. 1993 ; Vol. 1, No. 2. pp. 110-117.
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