Temporal lobe volume in panic disorder - A quantitative magnetic resonance imaging study

Meena Vythilingam, Eric R. Anderson, Andrew Goddard, Scott W. Woods, Lawrence H. Staib, Dennis S. Charney, J. Douglas Bremner

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Although previous studies have used magnetic resonance imaging (MRI) to demonstrate qualitative abnormalities of the temporal lobes in patients with panic disorder, no study to date has applied quantitative volumetric methods to evaluate brain changes in panic disorder. The purpose of this study was to measure the volume of the temporal lobe and the hippocampus in patients with panic disorder and healthy control subjects using quantitative MRI measures. The volume of the temporal lobe, hippocampus and whole brain was measured in 13 patients with panic disorder and 14 healthy subjects. The mean volume of the left and right temporal lobes was significantly smaller in panic disorder compared to healthy subjects (16770 ± 909 mm3 vs. 18343 ± 1740 mm3). This result was significant after controlling for differences in whole brain volume. There was no significant difference in volume of the hippocampus between patients and control subjects. These findings are consistent with smaller temporal lobe volume in panic disorder despite normal hippocampal volume. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume99
Issue number2
DOIs
StatePublished - Aug 28 2000
Externally publishedYes

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Panic Disorder
Temporal Lobe
Magnetic Resonance Imaging
Hippocampus
Healthy Volunteers
Brain

Keywords

  • Limbic system
  • Magnetic resonance imaging
  • Morphometry
  • Panic disorder
  • Temporal lobe volume

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Vythilingam, M., Anderson, E. R., Goddard, A., Woods, S. W., Staib, L. H., Charney, D. S., & Bremner, J. D. (2000). Temporal lobe volume in panic disorder - A quantitative magnetic resonance imaging study. Psychiatry Research - Neuroimaging, 99(2), 75-82. https://doi.org/10.1016/S0925-4927(00)00055-X

Temporal lobe volume in panic disorder - A quantitative magnetic resonance imaging study. / Vythilingam, Meena; Anderson, Eric R.; Goddard, Andrew; Woods, Scott W.; Staib, Lawrence H.; Charney, Dennis S.; Bremner, J. Douglas.

In: Psychiatry Research - Neuroimaging, Vol. 99, No. 2, 28.08.2000, p. 75-82.

Research output: Contribution to journalArticle

Vythilingam, M, Anderson, ER, Goddard, A, Woods, SW, Staib, LH, Charney, DS & Bremner, JD 2000, 'Temporal lobe volume in panic disorder - A quantitative magnetic resonance imaging study', Psychiatry Research - Neuroimaging, vol. 99, no. 2, pp. 75-82. https://doi.org/10.1016/S0925-4927(00)00055-X
Vythilingam, Meena ; Anderson, Eric R. ; Goddard, Andrew ; Woods, Scott W. ; Staib, Lawrence H. ; Charney, Dennis S. ; Bremner, J. Douglas. / Temporal lobe volume in panic disorder - A quantitative magnetic resonance imaging study. In: Psychiatry Research - Neuroimaging. 2000 ; Vol. 99, No. 2. pp. 75-82.
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