Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS

P. Vermathen, G. Ende, K. D. Laxer, J. A. Walker, R. C. Knowlton, N. M. Barbaro, G. B. Matson, M. W. Weiner

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

1H MRS imaging was obtained from 10 patients with mesial temporal lobe epilepsy before and after surgery. After surgery, metabolic recovery in the contralateral hippocampus was detected. Preoperatively, reduced N-acetylaspartate (p < 0.04) increased after surgery nonsignificantly to equal control values. Cholines increased after surgery (p < 0.02) and creatine-phosphocreatine showed a trend to higher values. The results suggest that the contralateral hippocampus is affected by repeated seizure activity in the ipsilateral hippocampus, rather than presence of bilateral mesial temporal sclerosis.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalNeurology
Volume59
Issue number4
DOIs
StatePublished - Aug 27 2002

ASJC Scopus subject areas

  • Clinical Neurology

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    Vermathen, P., Ende, G., Laxer, K. D., Walker, J. A., Knowlton, R. C., Barbaro, N. M., Matson, G. B., & Weiner, M. W. (2002). Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS. Neurology, 59(4), 633-636. https://doi.org/10.1212/WNL.59.4.633