Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS

P. Vermathen, G. Ende, K. D. Laxer, J. A. Walker, R. C. Knowlton, Nicholas Barbaro, G. B. Matson, M. W. Weiner

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

1H MRS imaging was obtained from 10 patients with mesial temporal lobe epilepsy before and after surgery. After surgery, metabolic recovery in the contralateral hippocampus was detected. Preoperatively, reduced N-acetylaspartate (p <0.04) increased after surgery nonsignificantly to equal control values. Cholines increased after surgery (p <0.02) and creatine-phosphocreatine showed a trend to higher values. The results suggest that the contralateral hippocampus is affected by repeated seizure activity in the ipsilateral hippocampus, rather than presence of bilateral mesial temporal sclerosis.

Original languageEnglish (US)
Pages (from-to)633-636
Number of pages4
JournalNeurology
Volume59
Issue number4
StatePublished - Aug 27 2002
Externally publishedYes

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Epilepsy
Hippocampus
Phosphocreatine
Temporal Lobe Epilepsy
Creatine
Sclerosis
Choline
Seizures
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Vermathen, P., Ende, G., Laxer, K. D., Walker, J. A., Knowlton, R. C., Barbaro, N., ... Weiner, M. W. (2002). Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS. Neurology, 59(4), 633-636.

Temporal lobectomy for epilepsy : Recovery of the contralateral hippocampus measured by 1H MRS. / Vermathen, P.; Ende, G.; Laxer, K. D.; Walker, J. A.; Knowlton, R. C.; Barbaro, Nicholas; Matson, G. B.; Weiner, M. W.

In: Neurology, Vol. 59, No. 4, 27.08.2002, p. 633-636.

Research output: Contribution to journalArticle

Vermathen, P, Ende, G, Laxer, KD, Walker, JA, Knowlton, RC, Barbaro, N, Matson, GB & Weiner, MW 2002, 'Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS', Neurology, vol. 59, no. 4, pp. 633-636.
Vermathen P, Ende G, Laxer KD, Walker JA, Knowlton RC, Barbaro N et al. Temporal lobectomy for epilepsy: Recovery of the contralateral hippocampus measured by 1H MRS. Neurology. 2002 Aug 27;59(4):633-636.
Vermathen, P. ; Ende, G. ; Laxer, K. D. ; Walker, J. A. ; Knowlton, R. C. ; Barbaro, Nicholas ; Matson, G. B. ; Weiner, M. W. / Temporal lobectomy for epilepsy : Recovery of the contralateral hippocampus measured by 1H MRS. In: Neurology. 2002 ; Vol. 59, No. 4. pp. 633-636.
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