Temporal trends and predictors of salvage cancer treatment after failure following radical prostatectomy or radiation therapy

An analysis from the CaPSURE registry

K. Clinton Cary, Alan Paciorek, Mahesh J. Fuldeore, Peter R. Carroll, Matthew R. Cooperberg

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

BACKGROUND Prostate cancer treatment after failure of primary therapy by either radical prostatectomy or radiation therapy can vary greatly. This study sought to determine trends and predictors of salvage treatment after failure of primary treatment in a community cohort over the past 10 years. METHODS From the community-based Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database, 6275 patients were identified who initiated a form of primary treatment for prostate cancer; 839 of these were identified as failing treatment by biochemical recurrence or initiation of secondary treatment between 2000 and 2010. Salvage therapy was categorized as either systemic, local, or none. Patient characteristics were tested for association with salvage therapy using analysis of variance, Pearson chi-square tests, and multinomial logistic regression analysis. RESULTS Of the 839 patients identified as failing therapy, 390 (47%), 146 (17%), and 303 (36%) received systemic, local, or no salvage therapy, respectively. Type of primary treatment received was associated with type of salvage therapy (P

Original languageEnglish (US)
Pages (from-to)507-512
Number of pages6
JournalCancer
Volume120
Issue number4
DOIs
StatePublished - Feb 15 2014
Externally publishedYes

Fingerprint

Salvage Therapy
Prostatectomy
Treatment Failure
Registries
Prostatic Neoplasms
Radiotherapy
Research
Neoplasms
Therapeutics
Chi-Square Distribution
Analysis of Variance
Logistic Models
Regression Analysis
Databases
Recurrence

Keywords

  • outcomes research
  • prostate cancer
  • recurrence
  • salvage therapy
  • trends

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Temporal trends and predictors of salvage cancer treatment after failure following radical prostatectomy or radiation therapy : An analysis from the CaPSURE registry. / Cary, K. Clinton; Paciorek, Alan; Fuldeore, Mahesh J.; Carroll, Peter R.; Cooperberg, Matthew R.

In: Cancer, Vol. 120, No. 4, 15.02.2014, p. 507-512.

Research output: Contribution to journalArticle

Cary, K. Clinton ; Paciorek, Alan ; Fuldeore, Mahesh J. ; Carroll, Peter R. ; Cooperberg, Matthew R. / Temporal trends and predictors of salvage cancer treatment after failure following radical prostatectomy or radiation therapy : An analysis from the CaPSURE registry. In: Cancer. 2014 ; Vol. 120, No. 4. pp. 507-512.
@article{ea36b45c21ce46878023b4847bbd88ef,
title = "Temporal trends and predictors of salvage cancer treatment after failure following radical prostatectomy or radiation therapy: An analysis from the CaPSURE registry",
abstract = "BACKGROUND Prostate cancer treatment after failure of primary therapy by either radical prostatectomy or radiation therapy can vary greatly. This study sought to determine trends and predictors of salvage treatment after failure of primary treatment in a community cohort over the past 10 years. METHODS From the community-based Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database, 6275 patients were identified who initiated a form of primary treatment for prostate cancer; 839 of these were identified as failing treatment by biochemical recurrence or initiation of secondary treatment between 2000 and 2010. Salvage therapy was categorized as either systemic, local, or none. Patient characteristics were tested for association with salvage therapy using analysis of variance, Pearson chi-square tests, and multinomial logistic regression analysis. RESULTS Of the 839 patients identified as failing therapy, 390 (47{\%}), 146 (17{\%}), and 303 (36{\%}) received systemic, local, or no salvage therapy, respectively. Type of primary treatment received was associated with type of salvage therapy (P",
keywords = "outcomes research, prostate cancer, recurrence, salvage therapy, trends",
author = "Cary, {K. Clinton} and Alan Paciorek and Fuldeore, {Mahesh J.} and Carroll, {Peter R.} and Cooperberg, {Matthew R.}",
year = "2014",
month = "2",
day = "15",
doi = "10.1002/cncr.28446",
language = "English (US)",
volume = "120",
pages = "507--512",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Temporal trends and predictors of salvage cancer treatment after failure following radical prostatectomy or radiation therapy

T2 - An analysis from the CaPSURE registry

AU - Cary, K. Clinton

AU - Paciorek, Alan

AU - Fuldeore, Mahesh J.

AU - Carroll, Peter R.

AU - Cooperberg, Matthew R.

PY - 2014/2/15

Y1 - 2014/2/15

N2 - BACKGROUND Prostate cancer treatment after failure of primary therapy by either radical prostatectomy or radiation therapy can vary greatly. This study sought to determine trends and predictors of salvage treatment after failure of primary treatment in a community cohort over the past 10 years. METHODS From the community-based Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database, 6275 patients were identified who initiated a form of primary treatment for prostate cancer; 839 of these were identified as failing treatment by biochemical recurrence or initiation of secondary treatment between 2000 and 2010. Salvage therapy was categorized as either systemic, local, or none. Patient characteristics were tested for association with salvage therapy using analysis of variance, Pearson chi-square tests, and multinomial logistic regression analysis. RESULTS Of the 839 patients identified as failing therapy, 390 (47%), 146 (17%), and 303 (36%) received systemic, local, or no salvage therapy, respectively. Type of primary treatment received was associated with type of salvage therapy (P

AB - BACKGROUND Prostate cancer treatment after failure of primary therapy by either radical prostatectomy or radiation therapy can vary greatly. This study sought to determine trends and predictors of salvage treatment after failure of primary treatment in a community cohort over the past 10 years. METHODS From the community-based Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) database, 6275 patients were identified who initiated a form of primary treatment for prostate cancer; 839 of these were identified as failing treatment by biochemical recurrence or initiation of secondary treatment between 2000 and 2010. Salvage therapy was categorized as either systemic, local, or none. Patient characteristics were tested for association with salvage therapy using analysis of variance, Pearson chi-square tests, and multinomial logistic regression analysis. RESULTS Of the 839 patients identified as failing therapy, 390 (47%), 146 (17%), and 303 (36%) received systemic, local, or no salvage therapy, respectively. Type of primary treatment received was associated with type of salvage therapy (P

KW - outcomes research

KW - prostate cancer

KW - recurrence

KW - salvage therapy

KW - trends

UR - http://www.scopus.com/inward/record.url?scp=84893776646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893776646&partnerID=8YFLogxK

U2 - 10.1002/cncr.28446

DO - 10.1002/cncr.28446

M3 - Article

VL - 120

SP - 507

EP - 512

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 4

ER -