Temporary Levodopa Withdrawal

Robert G. Feldman, Christopher G. Goetz, Caroline M. Tanner, Harold L. Klawans, William J. Weiner, Juan Sanchez-Ramos, Franz Hefti, Thomas Imperiale, Eran Y. Bellin, Richard Mayeux, Yaakov Stern, Lucien J. Cote, Kevin Mulvey

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

To the Editor: Mayeux et al. (Sept. 19 issue)1 studied a “drug holiday” from levodopa in patients with Parkinson's disease who had been subjects in a study of serotonin metabolism during depression. They were not selected because of levodopa toxicity or long-term–levodopa syndrome. Forty-nine patients completed the drug holiday, but only 28 were compared with a control group “randomly” chosen from 200 patients with Parkinson's disease. The group on the drug holiday had a longer mean time before initiation of levodopa (3.1±5.4 years) than the control group (1.8±2.1 years). Also, the control group had been taking lower doses to begin.

Original languageEnglish (US)
Pages (from-to)851-853
Number of pages3
JournalNew England Journal of Medicine
Volume314
Issue number13
DOIs
StatePublished - Mar 27 1986
Externally publishedYes

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Holidays
Levodopa
Control Groups
Parkinson Disease
Pharmaceutical Preparations
Serotonin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Feldman, R. G., Goetz, C. G., Tanner, C. M., Klawans, H. L., Weiner, W. J., Sanchez-Ramos, J., ... Mulvey, K. (1986). Temporary Levodopa Withdrawal. New England Journal of Medicine, 314(13), 851-853. https://doi.org/10.1056/NEJM198603273141314

Temporary Levodopa Withdrawal. / Feldman, Robert G.; Goetz, Christopher G.; Tanner, Caroline M.; Klawans, Harold L.; Weiner, William J.; Sanchez-Ramos, Juan; Hefti, Franz; Imperiale, Thomas; Bellin, Eran Y.; Mayeux, Richard; Stern, Yaakov; Cote, Lucien J.; Mulvey, Kevin.

In: New England Journal of Medicine, Vol. 314, No. 13, 27.03.1986, p. 851-853.

Research output: Contribution to journalLetter

Feldman, RG, Goetz, CG, Tanner, CM, Klawans, HL, Weiner, WJ, Sanchez-Ramos, J, Hefti, F, Imperiale, T, Bellin, EY, Mayeux, R, Stern, Y, Cote, LJ & Mulvey, K 1986, 'Temporary Levodopa Withdrawal', New England Journal of Medicine, vol. 314, no. 13, pp. 851-853. https://doi.org/10.1056/NEJM198603273141314
Feldman RG, Goetz CG, Tanner CM, Klawans HL, Weiner WJ, Sanchez-Ramos J et al. Temporary Levodopa Withdrawal. New England Journal of Medicine. 1986 Mar 27;314(13):851-853. https://doi.org/10.1056/NEJM198603273141314
Feldman, Robert G. ; Goetz, Christopher G. ; Tanner, Caroline M. ; Klawans, Harold L. ; Weiner, William J. ; Sanchez-Ramos, Juan ; Hefti, Franz ; Imperiale, Thomas ; Bellin, Eran Y. ; Mayeux, Richard ; Stern, Yaakov ; Cote, Lucien J. ; Mulvey, Kevin. / Temporary Levodopa Withdrawal. In: New England Journal of Medicine. 1986 ; Vol. 314, No. 13. pp. 851-853.
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