Temporary Levodopa Withdrawal

Robert G. Feldman, Christopher G. Goetz, Caroline M. Tanner, Harold L. Klawans, William J. Weiner, Juan Sanchez-Ramos, Franz Hefti, Thomas F. Imperiale, Eran Y. Bellin, Richard Mayeux, Yaakov Stern, Lucien J. Cote, Kevin Mulvey

Research output: Contribution to journalLetter

1 Scopus citations


To the Editor: Mayeux et al. (Sept. 19 issue)1 studied a “drug holiday” from levodopa in patients with Parkinson's disease who had been subjects in a study of serotonin metabolism during depression. They were not selected because of levodopa toxicity or long-term–levodopa syndrome. Forty-nine patients completed the drug holiday, but only 28 were compared with a control group “randomly” chosen from 200 patients with Parkinson's disease. The group on the drug holiday had a longer mean time before initiation of levodopa (3.1±5.4 years) than the control group (1.8±2.1 years). Also, the control group had been taking lower doses to begin.

Original languageEnglish (US)
Pages (from-to)851-853
Number of pages3
JournalNew England Journal of Medicine
Issue number13
StatePublished - Mar 27 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Feldman, R. G., Goetz, C. G., Tanner, C. M., Klawans, H. L., Weiner, W. J., Sanchez-Ramos, J., Hefti, F., Imperiale, T. F., Bellin, E. Y., Mayeux, R., Stern, Y., Cote, L. J., & Mulvey, K. (1986). Temporary Levodopa Withdrawal. New England Journal of Medicine, 314(13), 851-853. https://doi.org/10.1056/NEJM198603273141314