Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease

Andrea C. Solomon, Julie C. Stout, Marjorie Weaver, Sarah Queller, Allison Tomusk, Kathryn Burr Whitlock, Siu L. Hui, Jeanine Marshall, Jacqueline G. Jackson, Eric R. Siemens, Xabier Beristain, Joanne Wojcieszek, Tatiana Foroud

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre-HD) have been few, and duration of follow-up has been brief. In this study, 155 individuals at-risk for HD completed a battery of cognitive and motor tasks at two study 10 years apart. Participants were classified as: (1) at-risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre-HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the non-converters. These findings suggest that neurocognitive decline in pre-HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset.

Original languageEnglish (US)
Pages (from-to)1830-1836
Number of pages7
JournalMovement Disorders
Volume23
Issue number13
DOIs
StatePublished - Oct 15 2008

Keywords

  • Huntington disease
  • Longitudinal
  • Neurocognitive
  • Prediagnosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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