Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease

Andrea C. Solomon, Julie C. Stout, Marjorie Weaver, Sarah Queller, Allison Tomusk, Kathryn Burr Whitlock, Siu Hui, Jeanine Marshall, Jacqueline G. Jackson, Eric R. Siemens, Xabier Beristain, Joanne Wojcieszek, Tatiana Foroud

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Longitudinal studies of neurocognitive function in prediagnosis Huntington disease (pre-HD) have been few, and duration of follow-up has been brief. In this study, 155 individuals at-risk for HD completed a battery of cognitive and motor tasks at two study 10 years apart. Participants were classified as: (1) at-risk, without the CAG expansion (healthy controls, NC; n = 112), or (2) CAG expanded (CAG+; n = 43). To examine the rate of decline at different stages of the pre-HD period, participants in the CAG+ group were further characterized as converters (i.e., individuals who developed manifest HD over the course of the study; n = 21) or nonconverters (n = 22), and their performances were compared. The CAG+ group exhibited faster rates of neurocognitive decline over the course of the study, relative to the NC group. In addition, more rapid decline was associated with closer proximity to estimated age of disease onset in the CAG+ group. Faster rates of motor and psychomotor decline were observed in the CAG+ converter group, relative to the non-converters. These findings suggest that neurocognitive decline in pre-HD, particularly in motor and psychomotor domains, begins insidiously and accelerates as individuals approach disease onset.

Original languageEnglish
Pages (from-to)1830-1836
Number of pages7
JournalMovement Disorders
Volume23
Issue number13
DOIs
StatePublished - Oct 15 2008

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Huntington Disease
Age of Onset
Longitudinal Studies

Keywords

  • Huntington disease
  • Longitudinal
  • Neurocognitive
  • Prediagnosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease. / Solomon, Andrea C.; Stout, Julie C.; Weaver, Marjorie; Queller, Sarah; Tomusk, Allison; Whitlock, Kathryn Burr; Hui, Siu; Marshall, Jeanine; Jackson, Jacqueline G.; Siemens, Eric R.; Beristain, Xabier; Wojcieszek, Joanne; Foroud, Tatiana.

In: Movement Disorders, Vol. 23, No. 13, 15.10.2008, p. 1830-1836.

Research output: Contribution to journalArticle

Solomon, AC, Stout, JC, Weaver, M, Queller, S, Tomusk, A, Whitlock, KB, Hui, S, Marshall, J, Jackson, JG, Siemens, ER, Beristain, X, Wojcieszek, J & Foroud, T 2008, 'Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease', Movement Disorders, vol. 23, no. 13, pp. 1830-1836. https://doi.org/10.1002/mds.22097
Solomon AC, Stout JC, Weaver M, Queller S, Tomusk A, Whitlock KB et al. Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease. Movement Disorders. 2008 Oct 15;23(13):1830-1836. https://doi.org/10.1002/mds.22097
Solomon, Andrea C. ; Stout, Julie C. ; Weaver, Marjorie ; Queller, Sarah ; Tomusk, Allison ; Whitlock, Kathryn Burr ; Hui, Siu ; Marshall, Jeanine ; Jackson, Jacqueline G. ; Siemens, Eric R. ; Beristain, Xabier ; Wojcieszek, Joanne ; Foroud, Tatiana. / Ten-year rate of longitudinal change in neurocognitive and motor function in prediagnosis Huntington disease. In: Movement Disorders. 2008 ; Vol. 23, No. 13. pp. 1830-1836.
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