Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese

Wanqing Liu, Niufan Gu, Guoyin Feng, Sheng Li, Shaochun Bai, Jiangang Zhang, Tao Shen, Hong Xue, Gerome Breen, David St Clair, Lin He

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The serotonin transporter gene (SERT) plays an important role in the serotonin uptake into neurons. Recently, several polymorphisms including a variable-number-tandem-repeat (VNTR) in the second intron and an insertion/deletion polymorphism (5-HTT linked polymorphic region, 5-HTTLPR) were identified and reported to be associated with a variety of mental illnesses, including major depression, bipolar disorder, anxiety-related traits, and autism. In our study, we performed an association study between the SERT VNTR polymorphism and schizophrenia (n = 260), bipolar disorder (n = 137), and unipolar depression (n = 33) in the Han Chinese. A large group of ethnically matched control individuals (n = 362) were also genotyped. Allele 12 of the VNTR polymorphism was associated with schizophrenia (P = 0.007) and unipolar depression (P = 0.011). Bipolar disorder was not associated with the VNTR (P = 0.93). Thus, we conclude that the SERT VNTR polymorphism may be a risk factor for both schizophrenia and unipolar depression, but not for bipolar disorder, in the Han Chinese.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalPharmacogenetics
Volume9
Issue number4
StatePublished - Sep 15 1999

Keywords

  • Bipolar disorder
  • Han-Chinese
  • Schizophrenia
  • Serotonin transporter
  • Unipolar depression
  • VNTR

ASJC Scopus subject areas

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese'. Together they form a unique fingerprint.

  • Cite this

    Liu, W., Gu, N., Feng, G., Li, S., Bai, S., Zhang, J., Shen, T., Xue, H., Breen, G., St Clair, D., & He, L. (1999). Tentative association of the serotonin transporter with schizophrenia and unipolar depression but not with bipolar disorder in Han Chinese. Pharmacogenetics, 9(4), 491-495.