Teratomatous genotype detected in malignancies of a non-germ cell phenotype

Mojgan Devouassoux-Shisheboran, Alexander Vortmeyer, Susan A. Silver, Zhengping Zhuang, Fattaneh A. Tavassoli

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Originating from post-meiotic germ cells, mature ovarian teratomas (MOT) are genetically homozygous tumors within heterozygous hosts. MOT may be associated with malignant tumors of a non-germ cell phenotype (so-called malignant transformation). Based on the presence of in situ changes, some cases have been hypothesized to arise from teratomatous tissue. However, other malignancies associated with mature teratomas, such as sarcomas, may originate from either teratomatous elements or preexisting somatic ovarian tissue. Eight cases of MOT containing various histologic types of malignancy, including four squamous cell carcinomas, two sarcomas, one thyroid carcinoma, and one carcinoid tumor, were selected for study. Using selective tissue microdissection and PCR-based analysis of the extracted DNA, we compared the genotypic pattern of the mature teratomatous components to the associated malignant neoplasm with a random panel of highly informative genetic markers for different chromosomes. In all eight cases, genetic analysis of the malignant component revealed a homozygous genotype. In seven cases, the genetic profiles of mature teratomas and the associated malignant tumors were identical, suggesting a direct pathogenetic relationship between these lesions. In one case, the malignant component revealed homozygosity of different alleles compared with mature teratoma, suggesting independent teratomatous growth processes. This finding indicates that some ovarian malignancies of the non-germ cell phenotype arise in teratoma and fall into the spectrum of germ cell tumors.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalLaboratory Investigation
Volume80
Issue number1
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Teratoma
Genotype
Phenotype
Neoplasms
Sarcoma
Microdissection
Germ Cell and Embryonal Neoplasms
Carcinoid Tumor
Genetic Markers
Thyroid Neoplasms
Germ Cells
Squamous Cell Carcinoma
Chromosomes
Alleles
Polymerase Chain Reaction
DNA
Growth
Ovarian Teratoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Teratomatous genotype detected in malignancies of a non-germ cell phenotype. / Devouassoux-Shisheboran, Mojgan; Vortmeyer, Alexander; Silver, Susan A.; Zhuang, Zhengping; Tavassoli, Fattaneh A.

In: Laboratory Investigation, Vol. 80, No. 1, 01.01.2000, p. 81-86.

Research output: Contribution to journalArticle

Devouassoux-Shisheboran, M, Vortmeyer, A, Silver, SA, Zhuang, Z & Tavassoli, FA 2000, 'Teratomatous genotype detected in malignancies of a non-germ cell phenotype', Laboratory Investigation, vol. 80, no. 1, pp. 81-86. https://doi.org/10.1038/labinvest.3780011
Devouassoux-Shisheboran, Mojgan ; Vortmeyer, Alexander ; Silver, Susan A. ; Zhuang, Zhengping ; Tavassoli, Fattaneh A. / Teratomatous genotype detected in malignancies of a non-germ cell phenotype. In: Laboratory Investigation. 2000 ; Vol. 80, No. 1. pp. 81-86.
@article{e0f6c878869e48adbecd1e0700faa216,
title = "Teratomatous genotype detected in malignancies of a non-germ cell phenotype",
abstract = "Originating from post-meiotic germ cells, mature ovarian teratomas (MOT) are genetically homozygous tumors within heterozygous hosts. MOT may be associated with malignant tumors of a non-germ cell phenotype (so-called malignant transformation). Based on the presence of in situ changes, some cases have been hypothesized to arise from teratomatous tissue. However, other malignancies associated with mature teratomas, such as sarcomas, may originate from either teratomatous elements or preexisting somatic ovarian tissue. Eight cases of MOT containing various histologic types of malignancy, including four squamous cell carcinomas, two sarcomas, one thyroid carcinoma, and one carcinoid tumor, were selected for study. Using selective tissue microdissection and PCR-based analysis of the extracted DNA, we compared the genotypic pattern of the mature teratomatous components to the associated malignant neoplasm with a random panel of highly informative genetic markers for different chromosomes. In all eight cases, genetic analysis of the malignant component revealed a homozygous genotype. In seven cases, the genetic profiles of mature teratomas and the associated malignant tumors were identical, suggesting a direct pathogenetic relationship between these lesions. In one case, the malignant component revealed homozygosity of different alleles compared with mature teratoma, suggesting independent teratomatous growth processes. This finding indicates that some ovarian malignancies of the non-germ cell phenotype arise in teratoma and fall into the spectrum of germ cell tumors.",
author = "Mojgan Devouassoux-Shisheboran and Alexander Vortmeyer and Silver, {Susan A.} and Zhengping Zhuang and Tavassoli, {Fattaneh A.}",
year = "2000",
month = "1",
day = "1",
doi = "10.1038/labinvest.3780011",
language = "English (US)",
volume = "80",
pages = "81--86",
journal = "Laboratory Investigation",
issn = "0023-6837",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Teratomatous genotype detected in malignancies of a non-germ cell phenotype

AU - Devouassoux-Shisheboran, Mojgan

AU - Vortmeyer, Alexander

AU - Silver, Susan A.

AU - Zhuang, Zhengping

AU - Tavassoli, Fattaneh A.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Originating from post-meiotic germ cells, mature ovarian teratomas (MOT) are genetically homozygous tumors within heterozygous hosts. MOT may be associated with malignant tumors of a non-germ cell phenotype (so-called malignant transformation). Based on the presence of in situ changes, some cases have been hypothesized to arise from teratomatous tissue. However, other malignancies associated with mature teratomas, such as sarcomas, may originate from either teratomatous elements or preexisting somatic ovarian tissue. Eight cases of MOT containing various histologic types of malignancy, including four squamous cell carcinomas, two sarcomas, one thyroid carcinoma, and one carcinoid tumor, were selected for study. Using selective tissue microdissection and PCR-based analysis of the extracted DNA, we compared the genotypic pattern of the mature teratomatous components to the associated malignant neoplasm with a random panel of highly informative genetic markers for different chromosomes. In all eight cases, genetic analysis of the malignant component revealed a homozygous genotype. In seven cases, the genetic profiles of mature teratomas and the associated malignant tumors were identical, suggesting a direct pathogenetic relationship between these lesions. In one case, the malignant component revealed homozygosity of different alleles compared with mature teratoma, suggesting independent teratomatous growth processes. This finding indicates that some ovarian malignancies of the non-germ cell phenotype arise in teratoma and fall into the spectrum of germ cell tumors.

AB - Originating from post-meiotic germ cells, mature ovarian teratomas (MOT) are genetically homozygous tumors within heterozygous hosts. MOT may be associated with malignant tumors of a non-germ cell phenotype (so-called malignant transformation). Based on the presence of in situ changes, some cases have been hypothesized to arise from teratomatous tissue. However, other malignancies associated with mature teratomas, such as sarcomas, may originate from either teratomatous elements or preexisting somatic ovarian tissue. Eight cases of MOT containing various histologic types of malignancy, including four squamous cell carcinomas, two sarcomas, one thyroid carcinoma, and one carcinoid tumor, were selected for study. Using selective tissue microdissection and PCR-based analysis of the extracted DNA, we compared the genotypic pattern of the mature teratomatous components to the associated malignant neoplasm with a random panel of highly informative genetic markers for different chromosomes. In all eight cases, genetic analysis of the malignant component revealed a homozygous genotype. In seven cases, the genetic profiles of mature teratomas and the associated malignant tumors were identical, suggesting a direct pathogenetic relationship between these lesions. In one case, the malignant component revealed homozygosity of different alleles compared with mature teratoma, suggesting independent teratomatous growth processes. This finding indicates that some ovarian malignancies of the non-germ cell phenotype arise in teratoma and fall into the spectrum of germ cell tumors.

UR - http://www.scopus.com/inward/record.url?scp=0033968583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033968583&partnerID=8YFLogxK

U2 - 10.1038/labinvest.3780011

DO - 10.1038/labinvest.3780011

M3 - Article

VL - 80

SP - 81

EP - 86

JO - Laboratory Investigation

JF - Laboratory Investigation

SN - 0023-6837

IS - 1

ER -