Testicular and paratesticular pathology in the pediatric population

A 20 year experience at Riley hospital for children

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The goals of this study are to define the spectrum, incidence, and relative frequency of testicular and paratesticular lesions in a typical North American population of 6 million based on the analysis of pathology specimens. Twenty years of pathology reports from 1990 to 2009 of all testicular and paratesticular specimens were retrieved and analyzed from computerized databases of the single major pediatric hospital in the state of Indiana. We showed that the three most common benign lesions were vanishing testis, atrophy/cryptorchidism, and testis torsion, all showed left-sided predominance. The incidence and trends of the major pathology entities were also studied. Neoplasms represented roughly 10% of the total, with leukemia, rhabdomyosarcoma, teratoma, and mixed germ cell tumor occurring in decreasing frequency. Many of the neoplasms occurred at characteristic narrow age ranges, with overall interesting bimodal distribution or some with unique genetic background.

Original languageEnglish
Pages (from-to)404-408
Number of pages5
JournalPathology Research and Practice
Volume209
Issue number7
DOIs
StatePublished - Jul 2013

Fingerprint

Pediatrics
Pathology
Population
Pediatric Hospitals
Cryptorchidism
Rhabdomyosarcoma
Germ Cell and Embryonal Neoplasms
Incidence
Teratoma
Atrophy
Testis
Neoplasms
Leukemia
Databases
Genetic Background
Anorchia

Keywords

  • Intersex disorder
  • Mixed germ cell tumor
  • Paratesticular
  • Testicular

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

Cite this

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title = "Testicular and paratesticular pathology in the pediatric population: A 20 year experience at Riley hospital for children",
abstract = "The goals of this study are to define the spectrum, incidence, and relative frequency of testicular and paratesticular lesions in a typical North American population of 6 million based on the analysis of pathology specimens. Twenty years of pathology reports from 1990 to 2009 of all testicular and paratesticular specimens were retrieved and analyzed from computerized databases of the single major pediatric hospital in the state of Indiana. We showed that the three most common benign lesions were vanishing testis, atrophy/cryptorchidism, and testis torsion, all showed left-sided predominance. The incidence and trends of the major pathology entities were also studied. Neoplasms represented roughly 10{\%} of the total, with leukemia, rhabdomyosarcoma, teratoma, and mixed germ cell tumor occurring in decreasing frequency. Many of the neoplasms occurred at characteristic narrow age ranges, with overall interesting bimodal distribution or some with unique genetic background.",
keywords = "Intersex disorder, Mixed germ cell tumor, Paratesticular, Testicular",
author = "Rong Fan and Jianjun Zhang  and Liang Cheng and Jingmei Lin",
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T1 - Testicular and paratesticular pathology in the pediatric population

T2 - A 20 year experience at Riley hospital for children

AU - Fan, Rong

AU - Zhang , Jianjun

AU - Cheng, Liang

AU - Lin, Jingmei

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N2 - The goals of this study are to define the spectrum, incidence, and relative frequency of testicular and paratesticular lesions in a typical North American population of 6 million based on the analysis of pathology specimens. Twenty years of pathology reports from 1990 to 2009 of all testicular and paratesticular specimens were retrieved and analyzed from computerized databases of the single major pediatric hospital in the state of Indiana. We showed that the three most common benign lesions were vanishing testis, atrophy/cryptorchidism, and testis torsion, all showed left-sided predominance. The incidence and trends of the major pathology entities were also studied. Neoplasms represented roughly 10% of the total, with leukemia, rhabdomyosarcoma, teratoma, and mixed germ cell tumor occurring in decreasing frequency. Many of the neoplasms occurred at characteristic narrow age ranges, with overall interesting bimodal distribution or some with unique genetic background.

AB - The goals of this study are to define the spectrum, incidence, and relative frequency of testicular and paratesticular lesions in a typical North American population of 6 million based on the analysis of pathology specimens. Twenty years of pathology reports from 1990 to 2009 of all testicular and paratesticular specimens were retrieved and analyzed from computerized databases of the single major pediatric hospital in the state of Indiana. We showed that the three most common benign lesions were vanishing testis, atrophy/cryptorchidism, and testis torsion, all showed left-sided predominance. The incidence and trends of the major pathology entities were also studied. Neoplasms represented roughly 10% of the total, with leukemia, rhabdomyosarcoma, teratoma, and mixed germ cell tumor occurring in decreasing frequency. Many of the neoplasms occurred at characteristic narrow age ranges, with overall interesting bimodal distribution or some with unique genetic background.

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