Testicular microlithiasis in children and associated testicular cancer

Matthew L. Cooper, Martin Kaefer, Rong Fan, Richard C. Rink, S. Gregory Jennings, Boaz Karmazyn

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: To evaluate the prevalence of testicular microlithiasis (TM) in children who have undergone scrotal ultrasonography (US) and their association with testicular tumors. Materials and Methods: This HIPAA-compliant study with waiver of informed consent was approved by the institutional review board. From 2003 to 2012, all patients with scrotal US and report mentioning calcifications or microlithiasis and all patients with testicular tumors from pathology database were identified. US studies were evaluated for the type of TM (classic <5 microliths or limited ,5 microliths in a single view) and change in follow-up studies if available. Medical charts were reviewed for US indication, underlying medical conditions, and pathologic abnormalities, when available. Fisher exact test was used to analyze the association of testicular tumors and TM. Results: A total of 3370 boys had scrotal US, 83 (2%) of whom had TM or microcalcifications in the report. TM was usually bilateral (n = 62, 75%) and classic (n = 59, 71%) type. TM was significantly less common in those younger than 2 years of age than in older age groups (0.1% vs 3.1%, P <.0001). The most common indication for US was scrotal pain (40 of 83 patients, 48%), and the most common associated medical condition was cryptorchidism (nine of 83 patients, 11%). Testicular tumor was significantly more likely in boys with TM (12% vs 0.3%, P <.01). Five (83%) of six patients with premalignant or benign tumors had a premalignant condition (cryptochydism in two and Peutz-Jeghers syndrome in three). Four patients with TM had malignant testicular tumors, all diagnosed after the age of 16 years. Conclusion: TM has a prevalence of 2% in boys who undergo scrotal US. It is most commonly bilateral, classic type, and stable at follow-up studies. There is a significant association of TM and testicular tumors. Malignant tumors were seen only in adolescent boys.

Original languageEnglish
Pages (from-to)857-863
Number of pages7
JournalRadiology
Volume270
Issue number3
DOIs
StatePublished - 2014

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Testicular Neoplasms
Ultrasonography
Testicular Microlithiasis
Peutz-Jeghers Syndrome
Health Insurance Portability and Accountability Act
Calcinosis
Cryptorchidism
Research Ethics Committees
Informed Consent
Neoplasms
Age Groups
Databases
Pathology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Testicular microlithiasis in children and associated testicular cancer. / Cooper, Matthew L.; Kaefer, Martin; Fan, Rong; Rink, Richard C.; Jennings, S. Gregory; Karmazyn, Boaz.

In: Radiology, Vol. 270, No. 3, 2014, p. 857-863.

Research output: Contribution to journalArticle

Cooper, Matthew L. ; Kaefer, Martin ; Fan, Rong ; Rink, Richard C. ; Jennings, S. Gregory ; Karmazyn, Boaz. / Testicular microlithiasis in children and associated testicular cancer. In: Radiology. 2014 ; Vol. 270, No. 3. pp. 857-863.
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abstract = "Purpose: To evaluate the prevalence of testicular microlithiasis (TM) in children who have undergone scrotal ultrasonography (US) and their association with testicular tumors. Materials and Methods: This HIPAA-compliant study with waiver of informed consent was approved by the institutional review board. From 2003 to 2012, all patients with scrotal US and report mentioning calcifications or microlithiasis and all patients with testicular tumors from pathology database were identified. US studies were evaluated for the type of TM (classic <5 microliths or limited ,5 microliths in a single view) and change in follow-up studies if available. Medical charts were reviewed for US indication, underlying medical conditions, and pathologic abnormalities, when available. Fisher exact test was used to analyze the association of testicular tumors and TM. Results: A total of 3370 boys had scrotal US, 83 (2{\%}) of whom had TM or microcalcifications in the report. TM was usually bilateral (n = 62, 75{\%}) and classic (n = 59, 71{\%}) type. TM was significantly less common in those younger than 2 years of age than in older age groups (0.1{\%} vs 3.1{\%}, P <.0001). The most common indication for US was scrotal pain (40 of 83 patients, 48{\%}), and the most common associated medical condition was cryptorchidism (nine of 83 patients, 11{\%}). Testicular tumor was significantly more likely in boys with TM (12{\%} vs 0.3{\%}, P <.01). Five (83{\%}) of six patients with premalignant or benign tumors had a premalignant condition (cryptochydism in two and Peutz-Jeghers syndrome in three). Four patients with TM had malignant testicular tumors, all diagnosed after the age of 16 years. Conclusion: TM has a prevalence of 2{\%} in boys who undergo scrotal US. It is most commonly bilateral, classic type, and stable at follow-up studies. There is a significant association of TM and testicular tumors. Malignant tumors were seen only in adolescent boys.",
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N2 - Purpose: To evaluate the prevalence of testicular microlithiasis (TM) in children who have undergone scrotal ultrasonography (US) and their association with testicular tumors. Materials and Methods: This HIPAA-compliant study with waiver of informed consent was approved by the institutional review board. From 2003 to 2012, all patients with scrotal US and report mentioning calcifications or microlithiasis and all patients with testicular tumors from pathology database were identified. US studies were evaluated for the type of TM (classic <5 microliths or limited ,5 microliths in a single view) and change in follow-up studies if available. Medical charts were reviewed for US indication, underlying medical conditions, and pathologic abnormalities, when available. Fisher exact test was used to analyze the association of testicular tumors and TM. Results: A total of 3370 boys had scrotal US, 83 (2%) of whom had TM or microcalcifications in the report. TM was usually bilateral (n = 62, 75%) and classic (n = 59, 71%) type. TM was significantly less common in those younger than 2 years of age than in older age groups (0.1% vs 3.1%, P <.0001). The most common indication for US was scrotal pain (40 of 83 patients, 48%), and the most common associated medical condition was cryptorchidism (nine of 83 patients, 11%). Testicular tumor was significantly more likely in boys with TM (12% vs 0.3%, P <.01). Five (83%) of six patients with premalignant or benign tumors had a premalignant condition (cryptochydism in two and Peutz-Jeghers syndrome in three). Four patients with TM had malignant testicular tumors, all diagnosed after the age of 16 years. Conclusion: TM has a prevalence of 2% in boys who undergo scrotal US. It is most commonly bilateral, classic type, and stable at follow-up studies. There is a significant association of TM and testicular tumors. Malignant tumors were seen only in adolescent boys.

AB - Purpose: To evaluate the prevalence of testicular microlithiasis (TM) in children who have undergone scrotal ultrasonography (US) and their association with testicular tumors. Materials and Methods: This HIPAA-compliant study with waiver of informed consent was approved by the institutional review board. From 2003 to 2012, all patients with scrotal US and report mentioning calcifications or microlithiasis and all patients with testicular tumors from pathology database were identified. US studies were evaluated for the type of TM (classic <5 microliths or limited ,5 microliths in a single view) and change in follow-up studies if available. Medical charts were reviewed for US indication, underlying medical conditions, and pathologic abnormalities, when available. Fisher exact test was used to analyze the association of testicular tumors and TM. Results: A total of 3370 boys had scrotal US, 83 (2%) of whom had TM or microcalcifications in the report. TM was usually bilateral (n = 62, 75%) and classic (n = 59, 71%) type. TM was significantly less common in those younger than 2 years of age than in older age groups (0.1% vs 3.1%, P <.0001). The most common indication for US was scrotal pain (40 of 83 patients, 48%), and the most common associated medical condition was cryptorchidism (nine of 83 patients, 11%). Testicular tumor was significantly more likely in boys with TM (12% vs 0.3%, P <.01). Five (83%) of six patients with premalignant or benign tumors had a premalignant condition (cryptochydism in two and Peutz-Jeghers syndrome in three). Four patients with TM had malignant testicular tumors, all diagnosed after the age of 16 years. Conclusion: TM has a prevalence of 2% in boys who undergo scrotal US. It is most commonly bilateral, classic type, and stable at follow-up studies. There is a significant association of TM and testicular tumors. Malignant tumors were seen only in adolescent boys.

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