Testing the Metal of ERCC2 in predicting the response to platinum-based therapy

John J. Turchi, Derek S. Woods, Pamela VanderVere-Carozza

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

DNA repair has been shown to affect the cellular response to platinum-based therapy in a variety of cancers; however, translating this knowledge to the clinic has proven diffi cult and yielded mixed results. In this issue of Cancer Discovery , Van Allen and colleagues have analyzed responders and nonresponders to neoadjuvant platinum-based therapy with locally advanced urothelial cancer and identifi ed a series of mutations in the nucleotide excision repair (NER) gene ERCC2 that correlate with the response to platinum-based therapy. This work provides evidence that defects in NER can be exploited to maximize the effi cacy of conventional platinumbased chemotherapy.

Original languageEnglish (US)
Pages (from-to)1118-1119
Number of pages2
JournalCancer Discovery
Volume4
Issue number10
DOIs
StatePublished - Oct 1 2014

ASJC Scopus subject areas

  • Oncology

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