Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

Dawei Ma, Wengen Wu, Guoxin Yang, Jingya Li, Jia Li, Qizhuang Ye

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number1
DOIs
StatePublished - Jan 5 2004
Externally publishedYes

Keywords

  • MMP inhibitors
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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