Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

Dawei Ma, Wengen Wu, Guoxin Yang, Jingya Li, Jia Li, Qizhuang Ye

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.

Original languageEnglish (US)
Pages (from-to)47-50
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number1
DOIs
StatePublished - Jan 5 2004

Fingerprint

Tetrahydroisoquinolines
Matrix Metalloproteinase Inhibitors
Sulfonamides
Matrix Metalloproteinases
Isoenzymes

Keywords

  • MMP inhibitors
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. / Ma, Dawei; Wu, Wengen; Yang, Guoxin; Li, Jingya; Li, Jia; Ye, Qizhuang.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 1, 05.01.2004, p. 47-50.

Research output: Contribution to journalArticle

Ma, Dawei ; Wu, Wengen ; Yang, Guoxin ; Li, Jingya ; Li, Jia ; Ye, Qizhuang. / Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 1. pp. 47-50.
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